FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017441344> ?p ?o ?g. }

• W2017441344 endingPage "294" @default.
• W2017441344 startingPage "284" @default.
• W2017441344 abstract "Mutated variants of NOD2, a cytosolic Toll-like receptor (TLR) that recognizes bacterial peptidoglycan, are responsible for increased susceptibility to Crohn's disease (CD). TLRs and their related plant counterparts, the disease-resistance R proteins, undergo alternative splicing as a means of controlling activity. Here we report that regions of NOD2 RNA transcripts that encode the N-terminal and leucine-rich repeat (LRR) domains are alternatively spliced, potentially creating at least eight putative NOD2 variants. The most common variant is a short truncated isoform designated NOD2-short which terminates at residue position 820 leaving three LRR domains. An N-terminally spliced variant designated NOD2-190 contains only CARD1 and a partial CARD2 domain. The expression of transcripts encoding full-length and alternatively spliced forms of NOD2 was altered in blood mononuclear cells and monocytic cell lines stimulated by bacterial products. NOD2-short and NOD2-190 were inactive and unresponsive to muramyl dipeptide (MDP), but did not antagonize the activity of wild-type NOD2. Alternative splicing of NOD2 transcripts represents a potential mechanism by which the intracellular bacterial sensing activity of NOD2 is altered or down-regulated." @default.
• W2017441344 created "2016-06-24" @default.
• W2017441344 creator A5036776972 @default.
• W2017441344 creator A5046380772 @default.
• W2017441344 creator A5051501141 @default.
• W2017441344 creator A5068516295 @default.
• W2017441344 date "2007-01-01" @default.
• W2017441344 modified "2023-10-02" @default.
• W2017441344 title "Splicing of NOD2 (CARD15) RNA transcripts" @default.
• W2017441344 cites W1494075612 @default.
• W2017441344 cites W1514224413 @default.
• W2017441344 cites W1514955262 @default.
• W2017441344 cites W1585737615 @default.
• W2017441344 cites W1642457845 @default.
• W2017441344 cites W1670573097 @default.
• W2017441344 cites W1963827945 @default.
• W2017441344 cites W1981045929 @default.
• W2017441344 cites W1995321760 @default.
• W2017441344 cites W1996214557 @default.
• W2017441344 cites W1998395322 @default.
• W2017441344 cites W2003634035 @default.
• W2017441344 cites W2003784229 @default.
• W2017441344 cites W2010237936 @default.
• W2017441344 cites W2014679946 @default.
• W2017441344 cites W2030375090 @default.
• W2017441344 cites W2033012915 @default.
• W2017441344 cites W2040024879 @default.
• W2017441344 cites W2041170922 @default.
• W2017441344 cites W2046838847 @default.
• W2017441344 cites W2052127995 @default.
• W2017441344 cites W2052136236 @default.
• W2017441344 cites W2064868405 @default.
• W2017441344 cites W2067227310 @default.
• W2017441344 cites W2074888340 @default.
• W2017441344 cites W2075583035 @default.
• W2017441344 cites W2076622680 @default.
• W2017441344 cites W2078153497 @default.
• W2017441344 cites W2086607027 @default.
• W2017441344 cites W2091028482 @default.
• W2017441344 cites W2103851237 @default.
• W2017441344 cites W2110372095 @default.
• W2017441344 cites W2110590976 @default.
• W2017441344 cites W2111015801 @default.
• W2017441344 cites W2111900042 @default.
• W2017441344 cites W2112930450 @default.
• W2017441344 cites W2119502087 @default.
• W2017441344 cites W2119968907 @default.
• W2017441344 cites W2120506268 @default.
• W2017441344 cites W2125309974 @default.
• W2017441344 cites W2127406402 @default.
• W2017441344 cites W2132482634 @default.
• W2017441344 cites W2152532561 @default.
• W2017441344 cites W2153130127 @default.
• W2017441344 cites W2157339124 @default.
• W2017441344 cites W77890253 @default.
• W2017441344 doi "https://doi.org/10.1016/j.molimm.2006.03.009" @default.
• W2017441344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16675018" @default.
• W2017441344 hasPublicationYear "2007" @default.
• W2017441344 type Work @default.
• W2017441344 sameAs 2017441344 @default.
• W2017441344 citedByCount "24" @default.
• W2017441344 countsByYear W20174413442012 @default.
• W2017441344 countsByYear W20174413442013 @default.
• W2017441344 countsByYear W20174413442014 @default.
• W2017441344 countsByYear W20174413442015 @default.
• W2017441344 countsByYear W20174413442016 @default.
• W2017441344 countsByYear W20174413442017 @default.
• W2017441344 countsByYear W20174413442021 @default.
• W2017441344 crossrefType "journal-article" @default.
• W2017441344 hasAuthorship W2017441344A5036776972 @default.
• W2017441344 hasAuthorship W2017441344A5046380772 @default.
• W2017441344 hasAuthorship W2017441344A5051501141 @default.
• W2017441344 hasAuthorship W2017441344A5068516295 @default.
• W2017441344 hasConcept C104317684 @default.
• W2017441344 hasConcept C136449434 @default.
• W2017441344 hasConcept C170493617 @default.
• W2017441344 hasConcept C194583182 @default.
• W2017441344 hasConcept C2776444769 @default.
• W2017441344 hasConcept C53345823 @default.
• W2017441344 hasConcept C54355233 @default.
• W2017441344 hasConcept C54458228 @default.
• W2017441344 hasConcept C67705224 @default.
• W2017441344 hasConcept C73758832 @default.
• W2017441344 hasConcept C7573103 @default.
• W2017441344 hasConcept C86803240 @default.
• W2017441344 hasConcept C8891405 @default.
• W2017441344 hasConcept C95444343 @default.
• W2017441344 hasConceptScore W2017441344C104317684 @default.
• W2017441344 hasConceptScore W2017441344C136449434 @default.
• W2017441344 hasConceptScore W2017441344C170493617 @default.
• W2017441344 hasConceptScore W2017441344C194583182 @default.
• W2017441344 hasConceptScore W2017441344C2776444769 @default.
• W2017441344 hasConceptScore W2017441344C53345823 @default.
• W2017441344 hasConceptScore W2017441344C54355233 @default.
• W2017441344 hasConceptScore W2017441344C54458228 @default.
• W2017441344 hasConceptScore W2017441344C67705224 @default.
• W2017441344 hasConceptScore W2017441344C73758832 @default.
• W2017441344 hasConceptScore W2017441344C7573103 @default.

• next