Matches in SemOpenAlex for { <https://semopenalex.org/work/W201744293> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W201744293 endingPage "22" @default.
- W201744293 startingPage "714" @default.
- W201744293 abstract "Patients with acne vulgaris often have impaired quality of life (QOL). The fixed-dose combination of benzoyl peroxide 5%/clindamycin 1% gel (BPO/C) topical gel provides an earlier onset of action and is more effective against inflammatory and total facial lesions than adapalene (AP) 0.1% gel.To compare BPO/C and AP with regard to the early effect on QOL, efficacy, and tolerability in patients with mild to moderate acne vulgaris.Patients were randomized to BPO/C or AP once nightly for 12 weeks in a multicentre, single-blind trial. The primary efficacy endpoint was QOL at week 2, assessed using the Skindex-29 questionnaire. Secondary endpoints included grading and counting of acne lesions; investigator assessments of peeling, erythema, and dryness, and patient-reported burning or itching. Adverse events were monitored during the study and during the 14-day minimum follow-up period.A total of 168 patients were enrolled, and 114 patients completed the study. In the intent-to-treat population, after 2 weeks of treatment, BPO/C was associated with a small but noticeably better improvement in global QOL compared with AP (-4.9 versus -1.1; P<0.001). A greater reduction in both total and inflammatory lesions was noted from week 1 onward (P<0.05) with BPO/C versus AP. At all time points, BPO/C was better tolerated than AP for all investigator-rated (dryness, peeling, erythema) and patient-rated (burning, itching) events (P<0.036).BPO/C is associated with early improvements in QOL compared with AP. These QOL improvements are likely to be the result of better efficacy and tolerability outcomes observed with BPO/C." @default.
- W201744293 created "2016-06-24" @default.
- W201744293 creator A5085858816 @default.
- W201744293 date "2012-06-01" @default.
- W201744293 modified "2023-10-03" @default.
- W201744293 title "Effects of benzoyl peroxide 5% clindamycin combination gel versus adapalene 0.1% on quality of life in patients with mild to moderate acne vulgaris: a randomized single-blind study." @default.
- W201744293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22648218" @default.
- W201744293 hasPublicationYear "2012" @default.
- W201744293 type Work @default.
- W201744293 sameAs 201744293 @default.
- W201744293 citedByCount "9" @default.
- W201744293 countsByYear W2017442932015 @default.
- W201744293 countsByYear W2017442932016 @default.
- W201744293 countsByYear W2017442932019 @default.
- W201744293 countsByYear W2017442932020 @default.
- W201744293 countsByYear W2017442932021 @default.
- W201744293 crossrefType "journal-article" @default.
- W201744293 hasAuthorship W201744293A5085858816 @default.
- W201744293 hasConcept C126322002 @default.
- W201744293 hasConcept C141071460 @default.
- W201744293 hasConcept C159110408 @default.
- W201744293 hasConcept C16005928 @default.
- W201744293 hasConcept C168563851 @default.
- W201744293 hasConcept C178790620 @default.
- W201744293 hasConcept C185592680 @default.
- W201744293 hasConcept C197934379 @default.
- W201744293 hasConcept C203092338 @default.
- W201744293 hasConcept C2776173921 @default.
- W201744293 hasConcept C2777140388 @default.
- W201744293 hasConcept C2777673923 @default.
- W201744293 hasConcept C2778375690 @default.
- W201744293 hasConcept C2778885487 @default.
- W201744293 hasConcept C2779121184 @default.
- W201744293 hasConcept C2779923671 @default.
- W201744293 hasConcept C2779951463 @default.
- W201744293 hasConcept C2780564577 @default.
- W201744293 hasConcept C44228677 @default.
- W201744293 hasConcept C521977710 @default.
- W201744293 hasConcept C71924100 @default.
- W201744293 hasConceptScore W201744293C126322002 @default.
- W201744293 hasConceptScore W201744293C141071460 @default.
- W201744293 hasConceptScore W201744293C159110408 @default.
- W201744293 hasConceptScore W201744293C16005928 @default.
- W201744293 hasConceptScore W201744293C168563851 @default.
- W201744293 hasConceptScore W201744293C178790620 @default.
- W201744293 hasConceptScore W201744293C185592680 @default.
- W201744293 hasConceptScore W201744293C197934379 @default.
- W201744293 hasConceptScore W201744293C203092338 @default.
- W201744293 hasConceptScore W201744293C2776173921 @default.
- W201744293 hasConceptScore W201744293C2777140388 @default.
- W201744293 hasConceptScore W201744293C2777673923 @default.
- W201744293 hasConceptScore W201744293C2778375690 @default.
- W201744293 hasConceptScore W201744293C2778885487 @default.
- W201744293 hasConceptScore W201744293C2779121184 @default.
- W201744293 hasConceptScore W201744293C2779923671 @default.
- W201744293 hasConceptScore W201744293C2779951463 @default.
- W201744293 hasConceptScore W201744293C2780564577 @default.
- W201744293 hasConceptScore W201744293C44228677 @default.
- W201744293 hasConceptScore W201744293C521977710 @default.
- W201744293 hasConceptScore W201744293C71924100 @default.
- W201744293 hasIssue "6" @default.
- W201744293 hasLocation W2017442931 @default.
- W201744293 hasOpenAccess W201744293 @default.
- W201744293 hasPrimaryLocation W2017442931 @default.
- W201744293 hasRelatedWork W155068864 @default.
- W201744293 hasRelatedWork W1730169 @default.
- W201744293 hasRelatedWork W201744293 @default.
- W201744293 hasRelatedWork W2035955639 @default.
- W201744293 hasRelatedWork W2239502113 @default.
- W201744293 hasRelatedWork W2373888137 @default.
- W201744293 hasRelatedWork W2472503628 @default.
- W201744293 hasRelatedWork W2801225356 @default.
- W201744293 hasRelatedWork W3132268980 @default.
- W201744293 hasRelatedWork W41365133 @default.
- W201744293 hasVolume "11" @default.
- W201744293 isParatext "false" @default.
- W201744293 isRetracted "false" @default.
- W201744293 magId "201744293" @default.
- W201744293 workType "article" @default.