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- W2017443018 abstract "A reduction of dopamine release or D2 receptor blockade in the terminal fields of the mesolimbic system clearly reduces conditioned fear. Injections of haloperidol, a preferential D2 receptor antagonist, into the inferior colliculus (IC) enhance the processing of unconditioned aversive information. However, a clear characterization of the interplay of D2 receptors in the mediation of unconditioned and conditioned fear is still lacking.The present study investigated the effects of intra-IC injections of the D2 receptor-selective antagonist sulpiride on behavior in the elevated plus maze (EPM), auditory-evoked potentials (AEPs) to loud sounds recorded from the IC, fear-potentiated startle (FPS), and conditioned freezing.Intra-IC injections of sulpiride caused clear proaversive effects in the EPM and enhanced AEPs induced by loud auditory stimuli. Intra-IC sulpiride administration did not affect FPS or conditioned freezing.Dopamine D2-like receptors of the inferior colliculus play a role in the modulation of unconditioned aversive information but not in the fear-potentiated startle response." @default.
- W2017443018 created "2016-06-24" @default.
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- W2017443018 date "2014-08-18" @default.
- W2017443018 modified "2023-09-30" @default.
- W2017443018 title "Dopamine D2-Like Receptors Modulate Unconditioned Fear: Role of the Inferior Colliculus" @default.
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- W2017443018 doi "https://doi.org/10.1371/journal.pone.0104228" @default.
- W2017443018 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4136794" @default.
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