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• W2017444199 abstract "The ability of many retroviruses to cause disease can be correlated to their cytopathic effect (CPE) in tissue culture characterized by an acute period of cell death and viral DNA accumulation. Here, we show that mutants of a subgroup B avian retrovirus (Alpharetrovirus) cause a very dramatic CPE in certain susceptible avian cells that is coincident with elevated levels of apoptosis, as measured by nuclear morphology, and persistent viral DNA accumulation. These mutants also have a broadly extended host range that includes rodent, cat, dog, monkey, and human cells (31). Previously, we have shown that the mutants exhibit diminished resistance to superinfection. The results presented here have important implications for the process of evolution of retroviruses to use distinct cellular receptors." @default.
• W2017444199 created "2016-06-24" @default.
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• W2017444199 date "2006-01-15" @default.
• W2017444199 modified "2023-10-10" @default.
• W2017444199 title "Evolution of Broad Host Range in Retroviruses Leads to Cell Death Mediated by Highly Cytopathic Variants" @default.
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• W2017444199 doi "https://doi.org/10.1128/jvi.80.2.562-570.2006" @default.
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