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- W2017444788 abstract "With the aim of obtaining potential IL-6 inhibitor for the treatment of rheumatoid arthritis, four 3-aryloxylindolizine derivatives were synthesized from the 2-bromopyridine and aryl propargyl ether through the Sonogashira coupling/ 5-endo-trig cycloisomerization domino strategy. These compounds were characterized by NMR, IR, EI-MS and elemental analysis. Their biological activities were evaluated by the bacterial lipopolysaccharide (LPS) stimulation of mouse cells on the RAW264.7 inflammation model. All the compounds revealed good anti-inflammatory activities with the inhibitions of 71~82% against IL-6 at 100 μM. The bioactive 3-aryloxylindolizines might be used as potential anti-inflammatory drugs." @default.
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- W2017444788 date "2013-09-01" @default.
- W2017444788 modified "2023-09-28" @default.
- W2017444788 title "Synthesis and Anti-Inflammatory Activity of 3-Aryloxylindolizine Derivatives via Sonogashira Coupling/<i>5-endo-trig</i> Cycloisomerization Domino Strategy" @default.
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- W2017444788 doi "https://doi.org/10.4028/www.scientific.net/amr.781-784.1093" @default.
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