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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017444876> ?p ?o ?g. }

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• W2017444876 abstract "Cortical spreading depression (CSD) is an intense depolarization wave implicated in the pathophysiology of brain injury states and migraine aura. As Ca v 2.1 channels modulate CSD susceptibility, we tested gabapentin, which inhibits Ca v 2.1 through high-affinity binding to its α 2 δ subunit, on CSD susceptibility in anesthetized rats. Gabapentin, 100 or 200 mg/kg, elevated the electrical threshold for CSD and diminished recurrent CSDs evoked by topical KCl, when administered 1 hour before testing. With its favorable safety and tolerability profile, gabapentin may have a role in suppression of injury depolarizations in stroke, intracranial hemorrhage, and traumatic brain injury." @default.
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• W2017444876 date "2010-06-30" @default.
• W2017444876 modified "2023-10-12" @default.
• W2017444876 title "Gabapentin Suppresses Cortical Spreading Depression Susceptibility" @default.
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• W2017444876 doi "https://doi.org/10.1038/jcbfm.2010.92" @default.
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