Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017446717> ?p ?o ?g. }
- W2017446717 endingPage "4232" @default.
- W2017446717 startingPage "4223" @default.
- W2017446717 abstract "The interaction of multiple HIV‐1 regulator of virion (Rev) proteins with the viral RNA target, the Rev response element (RRE), is critical for nuclear export of incompletely spliced and unspliced viral RNA, and for the onset of the late phase in the viral replication cycle. The heterogeneity of the Rev–RRE complex has made it difficult to study using conventional structural methods. In the present study, atomic force microscopy is applied to directly visualize the tertiary structure of the RRE RNA alone and in complex with Rev proteins. The appearance of the RRE is compatible with the earlier proposed RRE secondary structure in dimensions and overall shape, including a stalk and a head interpreted as stem I, and stem‐loops II–V in the secondary structure model, respectively. Atomic force microscopy imaging of the Rev–RRE complex revealed an increased height of the structure both in the stalk and head regions, which is in accordance with a binding model in which Rev binding to a high affinity site in stem IIB triggers oligomerization of Rev proteins through cooperative binding along stem I in RRE. The present study demonstrates that atomic force microscopy comprises a useful technique to study complex biological structures of nucleic acids at high resolution." @default.
- W2017446717 created "2016-06-24" @default.
- W2017446717 creator A5017942206 @default.
- W2017446717 creator A5033888778 @default.
- W2017446717 creator A5044478897 @default.
- W2017446717 creator A5072940644 @default.
- W2017446717 date "2009-07-14" @default.
- W2017446717 modified "2023-10-17" @default.
- W2017446717 title "Structure of the HIV‐1 Rev response element alone and in complex with regulator of virion (Rev) studied by atomic force microscopy" @default.
- W2017446717 cites W1490558618 @default.
- W2017446717 cites W1562998360 @default.
- W2017446717 cites W1576538493 @default.
- W2017446717 cites W1596124800 @default.
- W2017446717 cites W1851518464 @default.
- W2017446717 cites W1964033462 @default.
- W2017446717 cites W1964916693 @default.
- W2017446717 cites W1972715299 @default.
- W2017446717 cites W1975919410 @default.
- W2017446717 cites W1979451022 @default.
- W2017446717 cites W1985861003 @default.
- W2017446717 cites W1986174933 @default.
- W2017446717 cites W2008922773 @default.
- W2017446717 cites W2009818318 @default.
- W2017446717 cites W2015625581 @default.
- W2017446717 cites W2021637244 @default.
- W2017446717 cites W2030010042 @default.
- W2017446717 cites W2036358440 @default.
- W2017446717 cites W2037329697 @default.
- W2017446717 cites W2050121529 @default.
- W2017446717 cites W2051507077 @default.
- W2017446717 cites W2053965078 @default.
- W2017446717 cites W2056122035 @default.
- W2017446717 cites W2057132880 @default.
- W2017446717 cites W2059932934 @default.
- W2017446717 cites W2065350472 @default.
- W2017446717 cites W2071643046 @default.
- W2017446717 cites W2077430714 @default.
- W2017446717 cites W2083324135 @default.
- W2017446717 cites W2085623829 @default.
- W2017446717 cites W2087930337 @default.
- W2017446717 cites W2091653936 @default.
- W2017446717 cites W2094650831 @default.
- W2017446717 cites W2098434240 @default.
- W2017446717 cites W2103054297 @default.
- W2017446717 cites W2106397622 @default.
- W2017446717 cites W2114225171 @default.
- W2017446717 cites W2114241859 @default.
- W2017446717 cites W2117958114 @default.
- W2017446717 cites W2123425704 @default.
- W2017446717 cites W2124398596 @default.
- W2017446717 cites W2126182028 @default.
- W2017446717 cites W2140595736 @default.
- W2017446717 cites W2141157874 @default.
- W2017446717 cites W2145777296 @default.
- W2017446717 cites W2147717039 @default.
- W2017446717 cites W2171258458 @default.
- W2017446717 cites W2320383696 @default.
- W2017446717 cites W257454419 @default.
- W2017446717 doi "https://doi.org/10.1111/j.1742-4658.2009.07130.x" @default.
- W2017446717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19583776" @default.
- W2017446717 hasPublicationYear "2009" @default.
- W2017446717 type Work @default.
- W2017446717 sameAs 2017446717 @default.
- W2017446717 citedByCount "23" @default.
- W2017446717 countsByYear W20174467172012 @default.
- W2017446717 countsByYear W20174467172013 @default.
- W2017446717 countsByYear W20174467172014 @default.
- W2017446717 countsByYear W20174467172015 @default.
- W2017446717 countsByYear W20174467172016 @default.
- W2017446717 countsByYear W20174467172018 @default.
- W2017446717 countsByYear W20174467172019 @default.
- W2017446717 countsByYear W20174467172020 @default.
- W2017446717 countsByYear W20174467172022 @default.
- W2017446717 crossrefType "journal-article" @default.
- W2017446717 hasAuthorship W2017446717A5017942206 @default.
- W2017446717 hasAuthorship W2017446717A5033888778 @default.
- W2017446717 hasAuthorship W2017446717A5044478897 @default.
- W2017446717 hasAuthorship W2017446717A5072940644 @default.
- W2017446717 hasConcept C102951782 @default.
- W2017446717 hasConcept C104317684 @default.
- W2017446717 hasConcept C12554922 @default.
- W2017446717 hasConcept C138268822 @default.
- W2017446717 hasConcept C144027150 @default.
- W2017446717 hasConcept C154945302 @default.
- W2017446717 hasConcept C159047783 @default.
- W2017446717 hasConcept C171250308 @default.
- W2017446717 hasConcept C185592680 @default.
- W2017446717 hasConcept C192562407 @default.
- W2017446717 hasConcept C24107716 @default.
- W2017446717 hasConcept C2779560860 @default.
- W2017446717 hasConcept C3013748606 @default.
- W2017446717 hasConcept C41008148 @default.
- W2017446717 hasConcept C55493867 @default.
- W2017446717 hasConcept C62614982 @default.
- W2017446717 hasConcept C67705224 @default.
- W2017446717 hasConcept C6929976 @default.
- W2017446717 hasConcept C8010536 @default.
- W2017446717 hasConcept C86803240 @default.