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- W2017449375 abstract "The synthesis of (3R)-3-[Boc-Lys(biotinyl)-O]-11-cis-retinol bromoacetate and 3-[Boc-Lys(biotinyl)-O]-all trans-retinol chloroacetate is described. These biotinylated retinoids are instrumental in labeling the retinol binding proteins (RBPs) via a nucleophilic displacement of the haloacetate by a residue in the binding site of the protein. The covalently linked biotin will allow for a facile isolation and purification of the protein on a streptavidin column thus rendering the protein ready for a tryptic digest followed by mass spectrometric analysis. The 11-cis retinoid was synthesized via metal reduction of an alkyne intermediate generated from a Horner–Wadsworth–Emmons (HWE) reaction whereas the all-trans was synthesized via two consecutive HWE couplings." @default.
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- W2017449375 date "2002-08-01" @default.
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- W2017449375 title "Synthesis of biotinylated retinoids for cross-linking and isolation of retinol binding proteins" @default.
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- W2017449375 doi "https://doi.org/10.1016/s0040-4020(02)00667-1" @default.
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