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- W2017449430 endingPage "134" @default.
- W2017449430 startingPage "119" @default.
- W2017449430 abstract "Interferon-alpha (IFN-alpha) is a pleiotropic cytokine belonging to type I IFN, currently used in cancer patients. Early studies in mouse tumor models have shown the importance of host immune mechanisms in the generation of a long-lasting antitumor response to type I IFN. Recent studies have underscored new immunomodulatory effects of IFN-alpha, including activities on T and dendritic cells, which may explain IFN-induced tumor immunity. Reports on new immune correlates in cancer patients responding to IFN-alpha represent additional evidence on the importance of the interactions of IFN-alpha with the immune system for the generation of durable antitumor response. This knowledge, together with results from studies on genetically modified tumor cells expressing IFN-alpha, suggest novel strategies for using these cytokines in cancer immunotherapy and in particular the use of IFN-alpha as an immune adjuvant for the development of cancer vaccines." @default.
- W2017449430 created "2016-06-24" @default.
- W2017449430 creator A5004812966 @default.
- W2017449430 creator A5007239425 @default.
- W2017449430 creator A5009678390 @default.
- W2017449430 creator A5047393976 @default.
- W2017449430 date "2002-04-01" @default.
- W2017449430 modified "2023-09-30" @default.
- W2017449430 title "Interferon-alpha in tumor immunity and immunotherapy" @default.
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