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- W2017449922 abstract "The effect of thimerosal on cytosolic free Ca 2+ concentrations ([Ca 2+ ] i ) in human oral cancer cells (OC2) is unclear. This study explored whether thimerosal changed basal [Ca 2+ ] i levels in suspended OC2 cells using fura-2. Thimerosal at concentrations between 1and 50 μM increased [Ca 2+ ] i in a concentration-dependent manner. The Ca 2+ signal was reduced partly by removing extracellular Ca 2+ . Thimerosal-induced Ca 2+ influx was not blocked by L-type Ca 2+ entry inhibitors and protein kinase C modulators (phorbol 12-myristate 13-acetate [PMA] and GF109203X). In Ca 2+ -free medium, 50 μM thimerosal failed to induce a [Ca 2+ ] i rise after pretreatment with thapsigargin (an endoplasmic reticulum Ca 2+ pump inhibitor). Inhibition of phospholipase C with U73122 did not change thimerosal-induced [Ca 2+ ] i rises. At concentrations between 5 and 10 μM, thimerosal killed cells in a concentration-dependent manner. The cytotoxic effect of 8 μM thimerosal was potentiated by prechelating cytosolic Ca 2+ with the Ca 2+ chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetate/acetomethyl (BAPTA/ AM). Flow cytometry data suggested that 1—7 μM thimerosal-induced apoptosis in a concentration-dependent manner. Collectively, in OC2 cells, thimerosal-induced [Ca 2+ ] i rises by causing phospholipase C-independent Ca 2+ release from the endoplasmic reticulum and Ca 2+ influx through non—L-type Ca 2+ channels. Thimerosal killed cells in a concentration-dependent manner through apoptosis." @default.
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- W2017449922 date "2009-05-01" @default.
- W2017449922 modified "2023-10-16" @default.
- W2017449922 title "Effect of thimerosal on Ca2+ movement and viability in human oral cancer cells" @default.
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- W2017449922 doi "https://doi.org/10.1177/0960327109106548" @default.
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