FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017451004> ?p ?o ?g. }

• W2017451004 endingPage "1124" @default.
• W2017451004 startingPage "1113" @default.
• W2017451004 abstract "A heterotrimeric G alpha i subunit, alpha i-3, is localized on Golgi membranes in LLC-PK1 and NRK epithelial cells where it colocalizes with mannosidase II by immunofluorescence. The alpha i-3 was found to be localized on the cytoplasmic face of Golgi cisternae and it was distributed across the whole Golgi stack. The alpha i-3 subunit is found on isolated rat liver Golgi membranes by Western blotting and G alpha i-3 on the Golgi apparatus is ADP ribosylated by pertussis toxin. LLC-PK1 cells were stably transfected with G alpha i-3 on an MT-1, inducible promoter in order to overexpress alpha i-3 on Golgi membranes. The intracellular processing and constitutive secretion of the basement membrane heparan sulfate proteoglycan (HSPG) was measured in LLC-PK1 cells. Overexpression of alpha i-3 on Golgi membranes in transfected cells retarded the secretion of HSPG and accumulated precursors in the medial-trans-Golgi. This effect was reversed by treatment of cells with pertussis toxin which results in ADP-ribosylation and functional uncoupling of G alpha i-3 on Golgi membranes. These results provide evidence for a novel role for the pertussis toxin sensitive G alpha i-3 protein in Golgi trafficking of a constitutively secreted protein in epithelial cells." @default.
• W2017451004 created "2016-06-24" @default.
• W2017451004 creator A5042453107 @default.
• W2017451004 creator A5043435343 @default.
• W2017451004 creator A5052494090 @default.
• W2017451004 creator A5065489352 @default.
• W2017451004 creator A5070172117 @default.
• W2017451004 creator A5084665999 @default.
• W2017451004 date "1991-09-15" @default.
• W2017451004 modified "2023-10-15" @default.
• W2017451004 title "A heterotrimeric G protein, G alpha i-3, on Golgi membranes regulates the secretion of a heparan sulfate proteoglycan in LLC-PK1 epithelial cells." @default.
• W2017451004 cites W1485683585 @default.
• W2017451004 cites W1546578920 @default.
• W2017451004 cites W1568376229 @default.
• W2017451004 cites W1583347987 @default.
• W2017451004 cites W1593606055 @default.
• W2017451004 cites W1606227954 @default.
• W2017451004 cites W1625674924 @default.
• W2017451004 cites W163027896 @default.
• W2017451004 cites W1803364377 @default.
• W2017451004 cites W1969805452 @default.
• W2017451004 cites W1970435627 @default.
• W2017451004 cites W1976731691 @default.
• W2017451004 cites W1985700603 @default.
• W2017451004 cites W1987607664 @default.
• W2017451004 cites W1997321425 @default.
• W2017451004 cites W2008013667 @default.
• W2017451004 cites W2013026243 @default.
• W2017451004 cites W2016237398 @default.
• W2017451004 cites W2016417523 @default.
• W2017451004 cites W2020358132 @default.
• W2017451004 cites W2025871503 @default.
• W2017451004 cites W2031858572 @default.
• W2017451004 cites W2037887427 @default.
• W2017451004 cites W2039560400 @default.
• W2017451004 cites W2048421804 @default.
• W2017451004 cites W2057163724 @default.
• W2017451004 cites W2064916160 @default.
• W2017451004 cites W2065365365 @default.
• W2017451004 cites W2071802734 @default.
• W2017451004 cites W2073680356 @default.
• W2017451004 cites W2080875376 @default.
• W2017451004 cites W2092360229 @default.
• W2017451004 cites W2124485419 @default.
• W2017451004 cites W2139643413 @default.
• W2017451004 cites W2140093238 @default.
• W2017451004 cites W2144217770 @default.
• W2017451004 cites W2155378301 @default.
• W2017451004 cites W2179950846 @default.
• W2017451004 cites W2344846620 @default.
• W2017451004 doi "https://doi.org/10.1083/jcb.114.6.1113" @default.
• W2017451004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2289129" @default.
• W2017451004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1910049" @default.
• W2017451004 hasPublicationYear "1991" @default.
• W2017451004 type Work @default.
• W2017451004 sameAs 2017451004 @default.
• W2017451004 citedByCount "294" @default.
• W2017451004 countsByYear W20174510042012 @default.
• W2017451004 countsByYear W20174510042013 @default.
• W2017451004 countsByYear W20174510042014 @default.
• W2017451004 countsByYear W20174510042015 @default.
• W2017451004 countsByYear W20174510042016 @default.
• W2017451004 countsByYear W20174510042017 @default.
• W2017451004 countsByYear W20174510042018 @default.
• W2017451004 countsByYear W20174510042019 @default.
• W2017451004 countsByYear W20174510042020 @default.
• W2017451004 countsByYear W20174510042021 @default.
• W2017451004 countsByYear W20174510042022 @default.
• W2017451004 countsByYear W20174510042023 @default.
• W2017451004 crossrefType "journal-article" @default.
• W2017451004 hasAuthorship W2017451004A5042453107 @default.
• W2017451004 hasAuthorship W2017451004A5043435343 @default.
• W2017451004 hasAuthorship W2017451004A5052494090 @default.
• W2017451004 hasAuthorship W2017451004A5065489352 @default.
• W2017451004 hasAuthorship W2017451004A5070172117 @default.
• W2017451004 hasAuthorship W2017451004A5084665999 @default.
• W2017451004 hasBestOaLocation W20174510041 @default.
• W2017451004 hasConcept C104317684 @default.
• W2017451004 hasConcept C119062480 @default.
• W2017451004 hasConcept C139407321 @default.
• W2017451004 hasConcept C153911025 @default.
• W2017451004 hasConcept C158617107 @default.
• W2017451004 hasConcept C49039625 @default.
• W2017451004 hasConcept C49773422 @default.
• W2017451004 hasConcept C54009773 @default.
• W2017451004 hasConcept C55493867 @default.
• W2017451004 hasConcept C62478195 @default.
• W2017451004 hasConcept C80631254 @default.
• W2017451004 hasConcept C86803240 @default.
• W2017451004 hasConcept C95444343 @default.
• W2017451004 hasConceptScore W2017451004C104317684 @default.
• W2017451004 hasConceptScore W2017451004C119062480 @default.
• W2017451004 hasConceptScore W2017451004C139407321 @default.
• W2017451004 hasConceptScore W2017451004C153911025 @default.
• W2017451004 hasConceptScore W2017451004C158617107 @default.
• W2017451004 hasConceptScore W2017451004C49039625 @default.
• W2017451004 hasConceptScore W2017451004C49773422 @default.
• W2017451004 hasConceptScore W2017451004C54009773 @default.

• next