Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017452923> ?p ?o ?g. }
- W2017452923 endingPage "24" @default.
- W2017452923 startingPage "17" @default.
- W2017452923 abstract "Puberty is a critical period of development during which the reemergence of gonadotropin-releasing hormone secretion from the hypothalamus triggers a cascade of hormone-dependent processes. Maturation of specific brain regions including the prefrontal cortex occurs during this window, but the complex mechanisms underlying these dynamic changes are not well understood. Particularly, the potential involvement of epigenetics in this programming has been under-examined. The epigenome is known to guide earlier stages of development, and it is similarly poised to regulate vital pubertal-driven brain maturation. Further, as epigenetic machinery is highly environmentally responsive, its involvement may also lend this period of growth to greater vulnerability to external insults, resulting in reprogramming and increased disease risk. Importantly, neuropsychiatric diseases commonly present in individuals during or immediately following puberty, and environmental perturbations including stress may precipitate disease onset by disrupting the normal trajectory of pubertal brain development via epigenetic mechanisms. In this review, we discuss epigenetic processes involved in pubertal brain maturation, the potential points of derailment, and the importance of future studies for understanding this dynamic developmental window and gaining a better understanding of neuropsychiatric disease risk." @default.
- W2017452923 created "2016-06-24" @default.
- W2017452923 creator A5032882251 @default.
- W2017452923 creator A5051876711 @default.
- W2017452923 creator A5052080313 @default.
- W2017452923 creator A5057744124 @default.
- W2017452923 date "2014-04-01" @default.
- W2017452923 modified "2023-10-06" @default.
- W2017452923 title "Epigenetic mechanisms in pubertal brain maturation" @default.
- W2017452923 cites W144423133 @default.
- W2017452923 cites W1501280650 @default.
- W2017452923 cites W1554082852 @default.
- W2017452923 cites W1966656140 @default.
- W2017452923 cites W1968161691 @default.
- W2017452923 cites W1968248461 @default.
- W2017452923 cites W1968732609 @default.
- W2017452923 cites W1969205020 @default.
- W2017452923 cites W1970800077 @default.
- W2017452923 cites W1974725748 @default.
- W2017452923 cites W1976934495 @default.
- W2017452923 cites W1977623080 @default.
- W2017452923 cites W1978489297 @default.
- W2017452923 cites W1984111997 @default.
- W2017452923 cites W1987521821 @default.
- W2017452923 cites W1988163167 @default.
- W2017452923 cites W1988405549 @default.
- W2017452923 cites W1989362768 @default.
- W2017452923 cites W1989826158 @default.
- W2017452923 cites W2004539856 @default.
- W2017452923 cites W2006763459 @default.
- W2017452923 cites W2009119606 @default.
- W2017452923 cites W2014166259 @default.
- W2017452923 cites W2014443002 @default.
- W2017452923 cites W2015028692 @default.
- W2017452923 cites W2018847640 @default.
- W2017452923 cites W2026062838 @default.
- W2017452923 cites W2026570544 @default.
- W2017452923 cites W2029927321 @default.
- W2017452923 cites W2030063067 @default.
- W2017452923 cites W2031577596 @default.
- W2017452923 cites W2031843272 @default.
- W2017452923 cites W2039276157 @default.
- W2017452923 cites W2041058068 @default.
- W2017452923 cites W2048018606 @default.
- W2017452923 cites W2050555564 @default.
- W2017452923 cites W2050822362 @default.
- W2017452923 cites W2052593207 @default.
- W2017452923 cites W2053472601 @default.
- W2017452923 cites W2054980594 @default.
- W2017452923 cites W2056415305 @default.
- W2017452923 cites W2056667662 @default.
- W2017452923 cites W2058975031 @default.
- W2017452923 cites W2060969944 @default.
- W2017452923 cites W2061198654 @default.
- W2017452923 cites W2062267315 @default.
- W2017452923 cites W2063433474 @default.
- W2017452923 cites W2065566217 @default.
- W2017452923 cites W2070780249 @default.
- W2017452923 cites W2070882374 @default.
- W2017452923 cites W2070992907 @default.
- W2017452923 cites W2072047975 @default.
- W2017452923 cites W2073047972 @default.
- W2017452923 cites W2073697135 @default.
- W2017452923 cites W2075370186 @default.
- W2017452923 cites W2076173286 @default.
- W2017452923 cites W2081628235 @default.
- W2017452923 cites W2085369703 @default.
- W2017452923 cites W2090488936 @default.
- W2017452923 cites W2092177735 @default.
- W2017452923 cites W2093604260 @default.
- W2017452923 cites W2095190113 @default.
- W2017452923 cites W2100134745 @default.
- W2017452923 cites W2100751263 @default.
- W2017452923 cites W2106194989 @default.
- W2017452923 cites W2106957199 @default.
- W2017452923 cites W2111824942 @default.
- W2017452923 cites W2111869840 @default.
- W2017452923 cites W2115567488 @default.
- W2017452923 cites W2116806046 @default.
- W2017452923 cites W2119202572 @default.
- W2017452923 cites W2131832556 @default.
- W2017452923 cites W2133925293 @default.
- W2017452923 cites W2134816237 @default.
- W2017452923 cites W2143629083 @default.
- W2017452923 cites W2152292563 @default.
- W2017452923 cites W2155003921 @default.
- W2017452923 cites W2155048593 @default.
- W2017452923 cites W2158678922 @default.
- W2017452923 cites W2159178030 @default.
- W2017452923 cites W2165673819 @default.
- W2017452923 cites W2170425512 @default.
- W2017452923 cites W2171630722 @default.
- W2017452923 cites W2248237147 @default.
- W2017452923 cites W2413281882 @default.
- W2017452923 cites W4294333306 @default.
- W2017452923 doi "https://doi.org/10.1016/j.neuroscience.2013.11.014" @default.
- W2017452923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3959229" @default.
- W2017452923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24239720" @default.