FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017455836> ?p ?o ?g. }

• W2017455836 endingPage "e86454" @default.
• W2017455836 startingPage "e86454" @default.
• W2017455836 abstract "Functional expression of sweet taste receptors (T1R2 and T1R3) has been reported in numerous metabolic tissues, including the gut, pancreas, and, more recently, in adipose tissue. It has been suggested that sweet taste receptors in these non-gustatory tissues may play a role in systemic energy balance and metabolism. Smaller adipose depots have been reported in T1R3 knockout mice on a high carbohydrate diet, and sweet taste receptors have been reported to regulate adipogenesis in vitro. To assess the potential contribution of sweet taste receptors to adipose tissue biology, we investigated the adipose tissue phenotypes of T1R2 and T1R3 knockout mice. Here we provide data to demonstrate that when fed an obesogenic diet, both T1R2 and T1R3 knockout mice have reduced adiposity and smaller adipocytes. Although a mild glucose intolerance was observed with T1R3 deficiency, other metabolic variables analyzed were similar between genotypes. In addition, food intake, respiratory quotient, oxygen consumption, and physical activity were unchanged in T1R2 knockout mice. Although T1R2 deficiency did not affect adipocyte number in peripheral adipose depots, the number of bone marrow adipocytes is significantly reduced in these knockout animals. Finally, we present data demonstrating that T1R2 and T1R3 knockout mice have increased cortical bone mass and trabecular remodeling. This report identifies novel functions for sweet taste receptors in the regulation of adipose and bone biology, and suggests that in these contexts, T1R2 and T1R3 are either dependent on each other for activity or have common independent effects in vivo." @default.
• W2017455836 created "2016-06-24" @default.
• W2017455836 creator A5014684613 @default.
• W2017455836 creator A5027855604 @default.
• W2017455836 creator A5044822470 @default.
• W2017455836 creator A5047982252 @default.
• W2017455836 creator A5053254718 @default.
• W2017455836 creator A5055113366 @default.
• W2017455836 creator A5060138777 @default.
• W2017455836 creator A5062600742 @default.
• W2017455836 creator A5076309003 @default.
• W2017455836 creator A5077260684 @default.
• W2017455836 creator A5091519450 @default.
• W2017455836 date "2014-01-22" @default.
• W2017455836 modified "2023-10-16" @default.
• W2017455836 title "Sweet Taste Receptor Deficient Mice Have Decreased Adiposity and Increased Bone Mass" @default.
• W2017455836 cites W1541472311 @default.
• W2017455836 cites W1616790409 @default.
• W2017455836 cites W1660562446 @default.
• W2017455836 cites W1953103451 @default.
• W2017455836 cites W1975775502 @default.
• W2017455836 cites W1980338363 @default.
• W2017455836 cites W1982365101 @default.
• W2017455836 cites W1991018998 @default.
• W2017455836 cites W1992463553 @default.
• W2017455836 cites W1994404723 @default.
• W2017455836 cites W2005778832 @default.
• W2017455836 cites W2009275373 @default.
• W2017455836 cites W2010221831 @default.
• W2017455836 cites W2023939486 @default.
• W2017455836 cites W2043129312 @default.
• W2017455836 cites W2053712883 @default.
• W2017455836 cites W2057741125 @default.
• W2017455836 cites W2059117845 @default.
• W2017455836 cites W2071661010 @default.
• W2017455836 cites W2095839552 @default.
• W2017455836 cites W2099580424 @default.
• W2017455836 cites W2099666647 @default.
• W2017455836 cites W2120476264 @default.
• W2017455836 cites W2146158663 @default.
• W2017455836 cites W2155062256 @default.
• W2017455836 cites W2162535898 @default.
• W2017455836 cites W2163903769 @default.
• W2017455836 cites W2169714942 @default.
• W2017455836 cites W4237205057 @default.
• W2017455836 cites W4249590403 @default.
• W2017455836 doi "https://doi.org/10.1371/journal.pone.0086454" @default.
• W2017455836 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3899259" @default.
• W2017455836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24466105" @default.
• W2017455836 hasPublicationYear "2014" @default.
• W2017455836 type Work @default.
• W2017455836 sameAs 2017455836 @default.
• W2017455836 citedByCount "49" @default.
• W2017455836 countsByYear W20174558362014 @default.
• W2017455836 countsByYear W20174558362015 @default.
• W2017455836 countsByYear W20174558362016 @default.
• W2017455836 countsByYear W20174558362017 @default.
• W2017455836 countsByYear W20174558362018 @default.
• W2017455836 countsByYear W20174558362019 @default.
• W2017455836 countsByYear W20174558362020 @default.
• W2017455836 countsByYear W20174558362021 @default.
• W2017455836 countsByYear W20174558362022 @default.
• W2017455836 countsByYear W20174558362023 @default.
• W2017455836 crossrefType "journal-article" @default.
• W2017455836 hasAuthorship W2017455836A5014684613 @default.
• W2017455836 hasAuthorship W2017455836A5027855604 @default.
• W2017455836 hasAuthorship W2017455836A5044822470 @default.
• W2017455836 hasAuthorship W2017455836A5047982252 @default.
• W2017455836 hasAuthorship W2017455836A5053254718 @default.
• W2017455836 hasAuthorship W2017455836A5055113366 @default.
• W2017455836 hasAuthorship W2017455836A5060138777 @default.
• W2017455836 hasAuthorship W2017455836A5062600742 @default.
• W2017455836 hasAuthorship W2017455836A5076309003 @default.
• W2017455836 hasAuthorship W2017455836A5077260684 @default.
• W2017455836 hasAuthorship W2017455836A5091519450 @default.
• W2017455836 hasBestOaLocation W20174558361 @default.
• W2017455836 hasConcept C126322002 @default.
• W2017455836 hasConcept C134018914 @default.
• W2017455836 hasConcept C151955695 @default.
• W2017455836 hasConcept C170493617 @default.
• W2017455836 hasConcept C171089720 @default.
• W2017455836 hasConcept C182704531 @default.
• W2017455836 hasConcept C185592680 @default.
• W2017455836 hasConcept C2776175234 @default.
• W2017455836 hasConcept C71924100 @default.
• W2017455836 hasConcept C86803240 @default.
• W2017455836 hasConceptScore W2017455836C126322002 @default.
• W2017455836 hasConceptScore W2017455836C134018914 @default.
• W2017455836 hasConceptScore W2017455836C151955695 @default.
• W2017455836 hasConceptScore W2017455836C170493617 @default.
• W2017455836 hasConceptScore W2017455836C171089720 @default.
• W2017455836 hasConceptScore W2017455836C182704531 @default.
• W2017455836 hasConceptScore W2017455836C185592680 @default.
• W2017455836 hasConceptScore W2017455836C2776175234 @default.
• W2017455836 hasConceptScore W2017455836C71924100 @default.
• W2017455836 hasConceptScore W2017455836C86803240 @default.
• W2017455836 hasIssue "1" @default.
• W2017455836 hasLocation W20174558361 @default.

• next