FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017460037> ?p ?o ?g. }

• W2017460037 endingPage "357" @default.
• W2017460037 startingPage "354" @default.
• W2017460037 abstract "The purposes of this study were to estimate the relative dose potency (RP) of two formulations of salbutamol pressurized metered-dose inhalers (Proventil-HFA and Ventolin-CFC MDIs) to protect against methacholine bronchoconstriction, to validate this method and provide recommendations. The protective effects of 100-, 200-, and 400- μ g doses of Proventil-HFA were compared with the same doses of Ventolin-CFC in 18 adult asthmatics (mean FEV1, 92% predicted; mean baseline PC20 methacholine, 1.8 mg/ml), in a dose-level blind, balanced, eight-period, crossover, placebo-controlled study. The log-transformed PC20 values after each dose of the drugs were compared by repeated-measures analysis of variance (ANOVA). A significant dose-effect was present (p < 0.0001). Using the Finney assay, the RP of Proventil-HFA compared with Ventolin-CFC was 1.08 (90% CI, 0.81–1.46) (80% power). This was also estimated using a nonlinear Emax model to validate the Finney method. The most precise estimate of RP was obtained with the comparison between 100- and 200- μ g doses (RP, 1.00; 90% CI, 0.77–1.31). There were no adverse events resulting from the drugs or methacholine. We conclude that Proventil-HFA salbutamol is bioequivalent to Ventolin-CFC salbutamol. Bronchoprotection to methacholine is a valid method of demonstrating bioequivalence. By this method, 100- and 200- μ g doses of salbutamol inhalations from an MDI will suffice." @default.
• W2017460037 created "2016-06-24" @default.
• W2017460037 creator A5010412838 @default.
• W2017460037 creator A5026242254 @default.
• W2017460037 creator A5027185413 @default.
• W2017460037 creator A5042721578 @default.
• W2017460037 creator A5058697512 @default.
• W2017460037 creator A5071851202 @default.
• W2017460037 creator A5077189765 @default.
• W2017460037 date "1999-07-01" @default.
• W2017460037 modified "2023-09-26" @default.
• W2017460037 title "Protection against Methacholine Bronchoconstriction to Assess Relative Potency of Inhaled β₂-Agonist" @default.
• W2017460037 cites W1993147091 @default.
• W2017460037 cites W2006339508 @default.
• W2017460037 cites W2007237494 @default.
• W2017460037 cites W2049120461 @default.
• W2017460037 cites W2054656068 @default.
• W2017460037 cites W2066087580 @default.
• W2017460037 cites W2079718411 @default.
• W2017460037 cites W2087618837 @default.
• W2017460037 cites W2092027437 @default.
• W2017460037 cites W2313234758 @default.
• W2017460037 cites W4236639597 @default.
• W2017460037 doi "https://doi.org/10.1164/ajrccm.160.1.9812035" @default.
• W2017460037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10390425" @default.
• W2017460037 hasPublicationYear "1999" @default.
• W2017460037 type Work @default.
• W2017460037 sameAs 2017460037 @default.
• W2017460037 citedByCount "44" @default.
• W2017460037 countsByYear W20174600372012 @default.
• W2017460037 countsByYear W20174600372014 @default.
• W2017460037 countsByYear W20174600372015 @default.
• W2017460037 countsByYear W20174600372017 @default.
• W2017460037 countsByYear W20174600372018 @default.
• W2017460037 crossrefType "journal-article" @default.
• W2017460037 hasAuthorship W2017460037A5010412838 @default.
• W2017460037 hasAuthorship W2017460037A5026242254 @default.
• W2017460037 hasAuthorship W2017460037A5027185413 @default.
• W2017460037 hasAuthorship W2017460037A5042721578 @default.
• W2017460037 hasAuthorship W2017460037A5058697512 @default.
• W2017460037 hasAuthorship W2017460037A5071851202 @default.
• W2017460037 hasAuthorship W2017460037A5077189765 @default.
• W2017460037 hasConcept C112705442 @default.
• W2017460037 hasConcept C126322002 @default.
• W2017460037 hasConcept C142724271 @default.
• W2017460037 hasConcept C185592680 @default.
• W2017460037 hasConcept C202751555 @default.
• W2017460037 hasConcept C204787440 @default.
• W2017460037 hasConcept C27081682 @default.
• W2017460037 hasConcept C2776042228 @default.
• W2017460037 hasConcept C2776178081 @default.
• W2017460037 hasConcept C2777394947 @default.
• W2017460037 hasConcept C2777714996 @default.
• W2017460037 hasConcept C2780769369 @default.
• W2017460037 hasConcept C2781018748 @default.
• W2017460037 hasConcept C2781260171 @default.
• W2017460037 hasConcept C42219234 @default.
• W2017460037 hasConcept C42404028 @default.
• W2017460037 hasConcept C55493867 @default.
• W2017460037 hasConcept C57992300 @default.
• W2017460037 hasConcept C71924100 @default.
• W2017460037 hasConcept C87813604 @default.
• W2017460037 hasConcept C98274493 @default.
• W2017460037 hasConceptScore W2017460037C112705442 @default.
• W2017460037 hasConceptScore W2017460037C126322002 @default.
• W2017460037 hasConceptScore W2017460037C142724271 @default.
• W2017460037 hasConceptScore W2017460037C185592680 @default.
• W2017460037 hasConceptScore W2017460037C202751555 @default.
• W2017460037 hasConceptScore W2017460037C204787440 @default.
• W2017460037 hasConceptScore W2017460037C27081682 @default.
• W2017460037 hasConceptScore W2017460037C2776042228 @default.
• W2017460037 hasConceptScore W2017460037C2776178081 @default.
• W2017460037 hasConceptScore W2017460037C2777394947 @default.
• W2017460037 hasConceptScore W2017460037C2777714996 @default.
• W2017460037 hasConceptScore W2017460037C2780769369 @default.
• W2017460037 hasConceptScore W2017460037C2781018748 @default.
• W2017460037 hasConceptScore W2017460037C2781260171 @default.
• W2017460037 hasConceptScore W2017460037C42219234 @default.
• W2017460037 hasConceptScore W2017460037C42404028 @default.
• W2017460037 hasConceptScore W2017460037C55493867 @default.
• W2017460037 hasConceptScore W2017460037C57992300 @default.
• W2017460037 hasConceptScore W2017460037C71924100 @default.
• W2017460037 hasConceptScore W2017460037C87813604 @default.
• W2017460037 hasConceptScore W2017460037C98274493 @default.
• W2017460037 hasIssue "1" @default.
• W2017460037 hasLocation W20174600371 @default.
• W2017460037 hasLocation W20174600372 @default.
• W2017460037 hasOpenAccess W2017460037 @default.
• W2017460037 hasPrimaryLocation W20174600371 @default.
• W2017460037 hasRelatedWork W105678993 @default.
• W2017460037 hasRelatedWork W1982732664 @default.
• W2017460037 hasRelatedWork W2017460037 @default.
• W2017460037 hasRelatedWork W2019212858 @default.
• W2017460037 hasRelatedWork W2045227417 @default.
• W2017460037 hasRelatedWork W2066635153 @default.
• W2017460037 hasRelatedWork W2108123754 @default.
• W2017460037 hasRelatedWork W2148235335 @default.
• W2017460037 hasRelatedWork W2148313816 @default.

• next