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- W2017460080 abstract "Heart failure is an increasingly common syndrome, which is associated with a high 1-year mortality and significant morbidity. Currently ischaemic heart disease is the most common cause in western societies but the majority of causes produce a similar clinical picture of reduced cardiac output, salt and water retention and peripheral vasoconstriction. Advances in the understanding of the pathophysiology of heart failure have lead to an alteration in the way in which it is managed and the development of different models of heart failure. Salt and water retention is managed with the use of fluid restriction and diuretics. Inotropic therapy remains useful in the short-term management of heart failure when acute decompensation leads to critical hypoperfusion of vital organs. Finally the maladaptive neurohumoral activation found in heart failure can be antagonised by the use of beta-blockers, angiotensin converting enzyme inhibitors and spironolactone, all of which reduce mortality and improve symptoms." @default.
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- W2017460080 date "2001-10-01" @default.
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- W2017460080 title "Management of heart failure" @default.
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- W2017460080 doi "https://doi.org/10.1054/cacc.2000.0304" @default.
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