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• W2017460103 abstract "Nineteen carbazole alkaloids modified from heptaphylline (I) and 7-methoxyheptaphylline (II) isolated from Clausena harmandiana were synthesized. Among these derivatives, Ih and IIi showed cytotoxicity against the NCI-H187 cell line with IC50 values of 0.02 and 0.66 μM, respectively, which are about 138 and 4 fold stronger than the ellipticine standard. In addition, oxime Ih displayed cytotoxicity against KB cells with an IC50 value of 0.17 μM which is about 10 times stronger than the ellipticine. This compound demonstrated weak cytotoxicity against Vero cells (IC50 = 66.01 μM). The results show convincingly that Ih may be a promising lead for the development of cytotoxic agents." @default.
• W2017460103 created "2016-06-24" @default.
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• W2017460103 creator A5013894356 @default.
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• W2017460103 date "2011-09-01" @default.
• W2017460103 modified "2023-09-29" @default.
• W2017460103 title "Synthesis and cytotoxic activity of the heptaphylline and 7-methoxyheptaphylline series" @default.
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• W2017460103 doi "https://doi.org/10.1016/j.ejmech.2011.05.041" @default.
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