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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017462073> ?p ?o ?g. }

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• W2017462073 abstract "Mutations in the presenilin-1 (mutPS-1) gene, a cause of familial Alzheimer's disease, increase the susceptibility of neurons to apoptotic death. Using the trimethyltin model of hippocampal neurodegeneration, mice expressing the human mutPS-1 gene (M146L) exhibited increased neurodegeneration and mortality relative to non-transgenic littermates. Activation of NF-kappaB p50 was found to be impaired in transgenic mice with unaltered expression levels suggesting that mutPS-1 expression inhibits p50 activation to adversely affect neuronal resistance to injury." @default.
• W2017462073 created "2016-06-24" @default.
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• W2017462073 date "2003-01-01" @default.
• W2017462073 modified "2023-09-26" @default.
• W2017462073 title "Mice expressing human mutant presenilin-1 exhibit decreased activation of NF-κB p50 in hippocampal neurons after injury" @default.
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• W2017462073 doi "https://doi.org/10.1016/s0169-328x(02)00658-7" @default.
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