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• W2017463010 abstract "We evaluated the utility of the selective dopamine D_2/3 receptor ligand ¹⁸F-desmethoxyfallypride (¹⁸F-DMFP) for the differential diagnosis of patients with idiopathic parkinsonian syndrome (IPS) and nonidiopathic parkinsonian syndrome (non-IPS). On the basis of the superior sensitivity of PET, we hypothesized that ¹⁸F-DMFP should have properties for the differential diagnosis of these syndromes superior to what has been reported for the more conventional SPECT procedures. <b>Methods:</b> A series of 81 patients with parkinsonism (26 women, 55 men; mean age ± SD, 68 ± 11 y) were included in this retrospective analysis. A 30-min ¹⁸F-DMFP PET recording was acquired starting 1 h after injection of the tracer (180–200 MBq, intravenously). The specific binding (SB) in divisions of the striatum was calculated relative to the occipital cortex using an observer-independent semiautomatic volume-of-interest–based technique. The optimal SB threshold was defined by means of receiver-operating-characteristic analysis, which was also used for the evaluation of the diagnostic performance of SB, ratios between striatal subregions, and absolute asymmetries in SB. <b>Results:</b> Significant differences (<i>P</i> < 0.001) were found in striatal SB between IPS and non-IPS, most notably in the posterior putamen, for which the diagnostic power for discrimination of IPS and non-IPS was the highest (sensitivity, 87%; specificity, 96%; and accuracy, 91%). A further gain of diagnostic power (sensitivity, 92%; specificity, 96%; and accuracy, 94%) was obtained through discriminant analysis combining 3 parameters: SB of the posterior putamen, the posterior–to–anterior putamen ratio, and the posterior putamen–to–caudate ratio. <b>Conclusion:</b>¹⁸F-DMFP PET is useful for the differential diagnosis of IPS and non-IPS in patients with parkinsonism. The findings are consistent with relative sparing of D_2/3 receptors in the dopamine-denervated putamen of IPS patients, in contrast to a more substantial loss of striatal dopamine receptors in non-IPS patients. The PET procedure for this differential diagnosis was superior to the reported experience with ¹²³I-iodobenzamide SPECT." @default.
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• W2017463010 date "2010-03-17" @default.
• W2017463010 modified "2023-10-06" @default.
• W2017463010 title "The Value of the Dopamine D_2/3 Receptor Ligand ¹⁸F-Desmethoxyfallypride for the Differentiation of Idiopathic and Nonidiopathic Parkinsonian Syndromes" @default.
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• W2017463010 doi "https://doi.org/10.2967/jnumed.109.071811" @default.
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