FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017466013> ?p ?o ?g. }

• W2017466013 endingPage "435" @default.
• W2017466013 startingPage "432" @default.
• W2017466013 abstract "Protease-activated receptor-2 (PAR-2) and/or effector cell protease receptor-1 (EPR-1) may mediate the direct cellular actions of coagulation factor Xa in some cultured cell lines. The present study examined if factor Xa could actually evoke relaxation through either of these receptor systems in isolated rat aorta. Factor Xa at 8.5–85 nM, like the PAR-2-activators trypsin and SLIGRL-NH2, produced nitric oxide-dependent relaxation in the precontracted aortic rings. PAR-2 desensitization abolished relaxation responses to factor Xa as well as trypsin in the rings. The factor Xa interepidermal growth factor synthetic peptide L83FTRKL88(G)-NH2, known to block factor Xa binding to EPR-1, failed to inhibit factor Xa-evoked relaxation in the preparations. Our findings provide evidence that factor Xa evokes relaxation by activating PAR-2, but independently of EPR-1, in the rat aorta. The factor Xa-PAR-2 pathway might thus contribute to the severe hypotension during sepsis, in which multiple coagulation factors including factor X would become activated and PAR-2 would be induced." @default.
• W2017466013 created "2016-06-24" @default.
• W2017466013 creator A5031334106 @default.
• W2017466013 creator A5039950300 @default.
• W2017466013 creator A5044229650 @default.
• W2017466013 creator A5049639478 @default.
• W2017466013 creator A5050276095 @default.
• W2017466013 creator A5071857671 @default.
• W2017466013 date "2001-03-01" @default.
• W2017466013 modified "2023-10-05" @default.
• W2017466013 title "Factor Xa-Evoked Relaxation in Rat Aorta: Involvement of PAR-2" @default.
• W2017466013 cites W1518736614 @default.
• W2017466013 cites W1538605908 @default.
• W2017466013 cites W1595140077 @default.
• W2017466013 cites W1623022149 @default.
• W2017466013 cites W1656256413 @default.
• W2017466013 cites W1975006580 @default.
• W2017466013 cites W1983233834 @default.
• W2017466013 cites W1993246131 @default.
• W2017466013 cites W1999015815 @default.
• W2017466013 cites W2003571504 @default.
• W2017466013 cites W2006604622 @default.
• W2017466013 cites W2016830520 @default.
• W2017466013 cites W2017672336 @default.
• W2017466013 cites W2020186186 @default.
• W2017466013 cites W2029539300 @default.
• W2017466013 cites W2032425418 @default.
• W2017466013 cites W2037583192 @default.
• W2017466013 cites W2039822141 @default.
• W2017466013 cites W2053178620 @default.
• W2017466013 cites W2056515539 @default.
• W2017466013 cites W2058742965 @default.
• W2017466013 cites W2068751843 @default.
• W2017466013 cites W2071833026 @default.
• W2017466013 cites W2075378195 @default.
• W2017466013 cites W2082158969 @default.
• W2017466013 cites W2111902544 @default.
• W2017466013 cites W2147206646 @default.
• W2017466013 cites W310066127 @default.
• W2017466013 doi "https://doi.org/10.1006/bbrc.2001.4597" @default.
• W2017466013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11401477" @default.
• W2017466013 hasPublicationYear "2001" @default.
• W2017466013 type Work @default.
• W2017466013 sameAs 2017466013 @default.
• W2017466013 citedByCount "47" @default.
• W2017466013 countsByYear W20174660132013 @default.
• W2017466013 countsByYear W20174660132017 @default.
• W2017466013 countsByYear W20174660132020 @default.
• W2017466013 countsByYear W20174660132021 @default.
• W2017466013 crossrefType "journal-article" @default.
• W2017466013 hasAuthorship W2017466013A5031334106 @default.
• W2017466013 hasAuthorship W2017466013A5039950300 @default.
• W2017466013 hasAuthorship W2017466013A5044229650 @default.
• W2017466013 hasAuthorship W2017466013A5049639478 @default.
• W2017466013 hasAuthorship W2017466013A5050276095 @default.
• W2017466013 hasAuthorship W2017466013A5071857671 @default.
• W2017466013 hasConcept C12554922 @default.
• W2017466013 hasConcept C126322002 @default.
• W2017466013 hasConcept C134018914 @default.
• W2017466013 hasConcept C170493617 @default.
• W2017466013 hasConcept C181199279 @default.
• W2017466013 hasConcept C185592680 @default.
• W2017466013 hasConcept C2777292125 @default.
• W2017466013 hasConcept C2777444498 @default.
• W2017466013 hasConcept C2780340462 @default.
• W2017466013 hasConcept C519581460 @default.
• W2017466013 hasConcept C55493867 @default.
• W2017466013 hasConcept C71924100 @default.
• W2017466013 hasConcept C86803240 @default.
• W2017466013 hasConcept C89560881 @default.
• W2017466013 hasConceptScore W2017466013C12554922 @default.
• W2017466013 hasConceptScore W2017466013C126322002 @default.
• W2017466013 hasConceptScore W2017466013C134018914 @default.
• W2017466013 hasConceptScore W2017466013C170493617 @default.
• W2017466013 hasConceptScore W2017466013C181199279 @default.
• W2017466013 hasConceptScore W2017466013C185592680 @default.
• W2017466013 hasConceptScore W2017466013C2777292125 @default.
• W2017466013 hasConceptScore W2017466013C2777444498 @default.
• W2017466013 hasConceptScore W2017466013C2780340462 @default.
• W2017466013 hasConceptScore W2017466013C519581460 @default.
• W2017466013 hasConceptScore W2017466013C55493867 @default.
• W2017466013 hasConceptScore W2017466013C71924100 @default.
• W2017466013 hasConceptScore W2017466013C86803240 @default.
• W2017466013 hasConceptScore W2017466013C89560881 @default.
• W2017466013 hasIssue "2" @default.
• W2017466013 hasLocation W20174660131 @default.
• W2017466013 hasLocation W20174660132 @default.
• W2017466013 hasOpenAccess W2017466013 @default.
• W2017466013 hasPrimaryLocation W20174660131 @default.
• W2017466013 hasRelatedWork W1963919935 @default.
• W2017466013 hasRelatedWork W1979660518 @default.
• W2017466013 hasRelatedWork W2018368842 @default.
• W2017466013 hasRelatedWork W2033472167 @default.
• W2017466013 hasRelatedWork W2034583712 @default.
• W2017466013 hasRelatedWork W2063619316 @default.
• W2017466013 hasRelatedWork W2074821979 @default.
• W2017466013 hasRelatedWork W2162471541 @default.
• W2017466013 hasRelatedWork W2169225653 @default.

• next