FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017467490> ?p ?o ?g. }

• W2017467490 endingPage "4023" @default.
• W2017467490 startingPage "4023" @default.
• W2017467490 abstract "To investigate the role and clinicopathological significance of aberrant expression of Notch receptors and Delta-like ligand-4 (DLL4) in extrahepatic cholangiocarcinoma and gallbladder carcinoma.One hundred and ten patients had surgically resected extrahepatic cholangiocarcinoma (CC) and gallbladder carcinoma specimens examined by immunohistochemistry of available paraffin blocks. Immunohistochemistry was performed using anti-Notch receptors 1-4 and anti-DLL4 antibodies. We scored the immunopositivity of Notch receptors and DLL4 expression by percentage of positive tumor cells with cytoplasmic expression and intensity of immunostaining. Coexistent nuclear localization was evaluated. Clinicopathological parameters and survival data were compared with the expression of Notch receptors 1-4 and DLL4.Notch receptor proteins showed in the cytoplasm with or without nuclear expression in cancer cells, as well as showing weak cytoplasmic expression in non-neoplastic cells. By semiquantitative evaluation, positive immunostaining of Notch receptor 1 was detected in 96 cases (87.3%), Notch receptor 2 in 97 (88.2%), Notch receptor 3 in 97 (88.2%), Notch receptor 4 in 103 (93.6), and DLL4 in 84 (76.4%). In addition, coexistent nuclear localization was noted [Notch receptor 1; 18 cases (18.8%), Notch receptor 2; 40 (41.2%), Notch receptor 3; 32 (33.0%), Notch receptor 4; 99 (96.1%), DLL4; 48 (57.1%)]. Notch receptor 1 expression was correlated with advanced tumor, node, metastasis (TNM) stage (P = 0.043), Notch receptor 3 with advanced T stage (P = 0.017), tendency to express in cases with nodal metastasis (P = 0.065) and advanced TNM stage (P = 0.052). DLL4 expression tended to be related to less histological differentiation (P = 0.095). Coexistent nuclear localization of Notch receptor 3 was related to no nodal metastasis (P = 0.027) and Notch receptor 4 with less histological differentiation (P = 0.036), while DLL4 tended to be related inversely with T stage (P = 0.053). Coexistent nuclear localization of DLL4 was related to poor survival (P = 0.002).Aberrant expression of Notch receptors 1 and 3 play a role during cancer progression, and cytoplasmic nuclear coexistence of DLL4 expression correlates with poor survival in extrahepatic CC and gallbladder carcinoma." @default.
• W2017467490 created "2016-06-24" @default.
• W2017467490 creator A5034806512 @default.
• W2017467490 creator A5039461107 @default.
• W2017467490 creator A5056881722 @default.
• W2017467490 creator A5067036364 @default.
• W2017467490 creator A5078560149 @default.
• W2017467490 creator A5079411580 @default.
• W2017467490 creator A5083128249 @default.
• W2017467490 creator A5089745757 @default.
• W2017467490 date "2011-01-01" @default.
• W2017467490 modified "2023-10-15" @default.
• W2017467490 title "Clinicopathological significance of altered Notch signaling in extrahepatic cholangiocarcinoma and gallbladder carcinoma" @default.
• W2017467490 cites W1972670512 @default.
• W2017467490 cites W2000589976 @default.
• W2017467490 cites W2001957066 @default.
• W2017467490 cites W2018527149 @default.
• W2017467490 cites W2025188748 @default.
• W2017467490 cites W2035515971 @default.
• W2017467490 cites W2040224956 @default.
• W2017467490 cites W2040827891 @default.
• W2017467490 cites W2051319925 @default.
• W2017467490 cites W2058609662 @default.
• W2017467490 cites W2059289029 @default.
• W2017467490 cites W2061738087 @default.
• W2017467490 cites W2062711358 @default.
• W2017467490 cites W2082839004 @default.
• W2017467490 cites W2085682228 @default.
• W2017467490 cites W2108325039 @default.
• W2017467490 cites W2152700616 @default.
• W2017467490 cites W2154861644 @default.
• W2017467490 cites W2157930949 @default.
• W2017467490 cites W2171937023 @default.
• W2017467490 cites W2332605220 @default.
• W2017467490 doi "https://doi.org/10.3748/wjg.v17.i35.4023" @default.
• W2017467490 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3199562" @default.
• W2017467490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22046092" @default.
• W2017467490 hasPublicationYear "2011" @default.
• W2017467490 type Work @default.
• W2017467490 sameAs 2017467490 @default.
• W2017467490 citedByCount "39" @default.
• W2017467490 countsByYear W20174674902012 @default.
• W2017467490 countsByYear W20174674902013 @default.
• W2017467490 countsByYear W20174674902014 @default.
• W2017467490 countsByYear W20174674902015 @default.
• W2017467490 countsByYear W20174674902016 @default.
• W2017467490 countsByYear W20174674902017 @default.
• W2017467490 countsByYear W20174674902018 @default.
• W2017467490 countsByYear W20174674902019 @default.
• W2017467490 countsByYear W20174674902020 @default.
• W2017467490 countsByYear W20174674902021 @default.
• W2017467490 countsByYear W20174674902023 @default.
• W2017467490 crossrefType "journal-article" @default.
• W2017467490 hasAuthorship W2017467490A5034806512 @default.
• W2017467490 hasAuthorship W2017467490A5039461107 @default.
• W2017467490 hasAuthorship W2017467490A5056881722 @default.
• W2017467490 hasAuthorship W2017467490A5067036364 @default.
• W2017467490 hasAuthorship W2017467490A5078560149 @default.
• W2017467490 hasAuthorship W2017467490A5079411580 @default.
• W2017467490 hasAuthorship W2017467490A5083128249 @default.
• W2017467490 hasAuthorship W2017467490A5089745757 @default.
• W2017467490 hasBestOaLocation W20174674901 @default.
• W2017467490 hasConcept C126322002 @default.
• W2017467490 hasConcept C142724271 @default.
• W2017467490 hasConcept C161879069 @default.
• W2017467490 hasConcept C170493617 @default.
• W2017467490 hasConcept C204232928 @default.
• W2017467490 hasConcept C2777546739 @default.
• W2017467490 hasConcept C2780645649 @default.
• W2017467490 hasConcept C4224716 @default.
• W2017467490 hasConcept C502942594 @default.
• W2017467490 hasConcept C71924100 @default.
• W2017467490 hasConcept C86803240 @default.
• W2017467490 hasConceptScore W2017467490C126322002 @default.
• W2017467490 hasConceptScore W2017467490C142724271 @default.
• W2017467490 hasConceptScore W2017467490C161879069 @default.
• W2017467490 hasConceptScore W2017467490C170493617 @default.
• W2017467490 hasConceptScore W2017467490C204232928 @default.
• W2017467490 hasConceptScore W2017467490C2777546739 @default.
• W2017467490 hasConceptScore W2017467490C2780645649 @default.
• W2017467490 hasConceptScore W2017467490C4224716 @default.
• W2017467490 hasConceptScore W2017467490C502942594 @default.
• W2017467490 hasConceptScore W2017467490C71924100 @default.
• W2017467490 hasConceptScore W2017467490C86803240 @default.
• W2017467490 hasIssue "35" @default.
• W2017467490 hasLocation W20174674901 @default.
• W2017467490 hasLocation W20174674902 @default.
• W2017467490 hasLocation W20174674903 @default.
• W2017467490 hasLocation W20174674904 @default.
• W2017467490 hasOpenAccess W2017467490 @default.
• W2017467490 hasPrimaryLocation W20174674901 @default.
• W2017467490 hasRelatedWork W110523806 @default.
• W2017467490 hasRelatedWork W1546067550 @default.
• W2017467490 hasRelatedWork W1979893467 @default.
• W2017467490 hasRelatedWork W2056351008 @default.
• W2017467490 hasRelatedWork W2196023497 @default.
• W2017467490 hasRelatedWork W2347823473 @default.
• W2017467490 hasRelatedWork W2512703498 @default.

• next