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• W2017470983 abstract "Expression and distribution of adenosine diphosphate-ribosylation factors in the rat kidney.BackgroundAdenosine diphosphate (ADP)-ribosylation factors (ARFs) are small guanosine triphosphatases involved in membrane traffic regulation. Aiming to explore the possible involvement of ARF1 and ARF6 in the reabsorptive properties of the nephron, we evaluated their distribution along the different renal epithelial segments.MethodsARFs were detected by immunofluorescence and immunogold cytochemistry on renal sections, using specific anti-ARF antibodies.ResultsARF1 was detected in proximal and distal tubules, thick ascending limbs of Henle's loops, and cortical and medullary collecting ducts. By immunofluorescence, labeling was mostly localized to the cell cytoplasm, particularly in Golgi areas. By electron microscopy, the Golgi apparatus and the endosomal compartment of proximal and distal tubular cells were labeled. ARF6 immunofluorescence was observed in brush border membranes and the cytoplasm of proximal convoluted tubular cells, whereas it was restricted to the apical border of proximal straight tubules. ARF6 immunogold labeling was detected over microvilli and endocytic compartments of proximal tubular cells.ConclusionsThis study demonstrates the following: (a) the heterogeneous distributions of ARF1 and ARF6 along the nephron, (b) the existence of cytosolic and membrane-bound forms for both ARFs, and (c) their association with microvilli and endocytic compartments, suggesting an active participation in renal reabsorption. Expression and distribution of adenosine diphosphate-ribosylation factors in the rat kidney. Adenosine diphosphate (ADP)-ribosylation factors (ARFs) are small guanosine triphosphatases involved in membrane traffic regulation. Aiming to explore the possible involvement of ARF1 and ARF6 in the reabsorptive properties of the nephron, we evaluated their distribution along the different renal epithelial segments. ARFs were detected by immunofluorescence and immunogold cytochemistry on renal sections, using specific anti-ARF antibodies. ARF1 was detected in proximal and distal tubules, thick ascending limbs of Henle's loops, and cortical and medullary collecting ducts. By immunofluorescence, labeling was mostly localized to the cell cytoplasm, particularly in Golgi areas. By electron microscopy, the Golgi apparatus and the endosomal compartment of proximal and distal tubular cells were labeled. ARF6 immunofluorescence was observed in brush border membranes and the cytoplasm of proximal convoluted tubular cells, whereas it was restricted to the apical border of proximal straight tubules. ARF6 immunogold labeling was detected over microvilli and endocytic compartments of proximal tubular cells. This study demonstrates the following: (a) the heterogeneous distributions of ARF1 and ARF6 along the nephron, (b) the existence of cytosolic and membrane-bound forms for both ARFs, and (c) their association with microvilli and endocytic compartments, suggesting an active participation in renal reabsorption." @default.
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• W2017470983 title "Expression and distribution of adenosine diphosphate-ribosylation factors in the rat kidney111Present address is: Renal Unit & Program in Membrane Biology, Massachusetts General Hospital, Harvard Medical School, 149, 13th Street, 8th Floor, Boston, MA, 02129, USA" @default.
• W2017470983 cites W1498137861 @default.
• W2017470983 cites W1516922966 @default.
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• W2017470983 cites W1577792223 @default.
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• W2017470983 cites W1580161657 @default.
• W2017470983 cites W1958172963 @default.
• W2017470983 cites W1968774879 @default.
• W2017470983 cites W1976731691 @default.
• W2017470983 cites W1977598234 @default.
• W2017470983 cites W1981660336 @default.
• W2017470983 cites W1983437370 @default.
• W2017470983 cites W1986696160 @default.
• W2017470983 cites W1995084774 @default.
• W2017470983 cites W2002984398 @default.
• W2017470983 cites W2008009726 @default.
• W2017470983 cites W2008046589 @default.
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• W2017470983 cites W2016266703 @default.
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• W2017470983 cites W2043769210 @default.
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• W2017470983 cites W2081027637 @default.
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• W2017470983 cites W2119438819 @default.
• W2017470983 cites W2138510980 @default.
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• W2017470983 cites W2163909866 @default.
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• W2017470983 doi "https://doi.org/10.1046/j.1523-1755.1999.00365.x" @default.
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