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- W2017476077 abstract "Polymyositis is a CD8+ T-cell–mediated disease. T-cell clonal expansions are observed at disease onset, but little is known about their persistence over time. Qualitative and quantitative spectratyping demonstrated that PM relapse features dramatically perturbed blood T-cell repertoires but is not associated with the emergence of new T-cell clones. It is striking that patients in remission also maintained all their T-cell repertoire abnormalities. The clonally expanded T-cells displayed a memory phenotype, expressed intracellular perforin, and dramatically responded to IL-2, showing a potential to be reactivated upon appropriate conditions. These results indicate that persistent T-cell clonal expansion is an important feature of polymyositis. Ann Neurol 2004" @default.
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- W2017476077 date "2004-10-27" @default.
- W2017476077 modified "2023-10-17" @default.
- W2017476077 title "Long-term persistence of clonally expanded T cells in patients with polymyositis" @default.
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- W2017476077 doi "https://doi.org/10.1002/ana.20293" @default.
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