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• W2017477412 abstract "<i>Background:</i> Methotrexate (MTX) and cyclosporine (CYC) may adversely interact with common medications in patients with psoriasis. <i>Objective:</i> Our purpose was to investigate the prevalence and outcomes of MTX/CYC polypharmacy. <i>Methods:</i> We evaluated rates of events that may be associated with drug-related toxicity, health care resource utilization and costs for patients with psoriasis in the Ingenix® Impact National Managed Care Database (1999–2007) who were exposed or not exposed to potential drug-drug interactions. <i>Results:</i> Among 4,583 (57.6%) exposed and 3,372 (42.4%) nonexposed patients, nonsteroidal anti-inflammatory drugs and antibiotics were the most common drugs with potential interactions. The exposed patients had significantly greater risks of developing renal [adjusted odds ratio (OR): 2.58; p = 0.0145], gastrointestinal (OR: 1.36; p = 0.0197) and pulmonary events (OR: 1.20; p = 0.0470), and significantly greater health care resource utilization (e.g. OR for inpatient and emergency department visits: 1.47; p < 0.0001) and costs (adjusted incremental cost: USD 1,722; p < 0.0001). <i>Conclusions:</i> MTX/CYC polypharmacy is prevalent in patients with psoriasis and associated with significant risks." @default.
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• W2017477412 date "2010-01-01" @default.
• W2017477412 modified "2023-09-30" @default.
• W2017477412 title "High Prevalence of Potential Drug-Drug Interactions for Psoriasis Patients Prescribed Methotrexate or Cyclosporine for Psoriasis: Associated Clinical and Economic Outcomes in Real-World Practice" @default.
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• W2017477412 doi "https://doi.org/10.1159/000275198" @default.
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