Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017478720> ?p ?o ?g. }
- W2017478720 endingPage "5423" @default.
- W2017478720 startingPage "5418" @default.
- W2017478720 abstract "Pancreatic islets are avascular immediately after transplantation. Although the islets are rapidly revascularized, it is uncertain whether the revascularization produces an adequate oxygenation of the transplanted islet tissue. We measured pO(2), blood flow and vascular density in mouse or human islets 1 month after transplantation to nude mice. Tissue pO(2) was measured with Clark microelectrodes. Blood perfusion was measured with laser-Doppler flow cytometry, whereas vascular density was determined in histological specimens stained for the lectin Bandeiraea simplicifolia (BS-1). Both the transplanted mouse and human islets had a pO(2) 15-20% of that in endogenous mouse islets. Moreover, the vascular density of the transplanted islets was decreased compared with that of endogenous mouse and human islets. Graft blood perfusion was approximately 50% of renal cortex blood flow. A negative correlation was found between donor age and blood perfusion of the human islet grafts. A similar correlation was seen between donor age and the total vascular density of these grafts. In conclusion, transplanted human islets had a markedly decreased vascular density and pO(2) compared with endogenous islets. This has potential implications for clinical islet transplantations, because poor vascular engraftment may significantly increase the number of islets needed to obtain insulin independence." @default.
- W2017478720 created "2016-06-24" @default.
- W2017478720 creator A5019273811 @default.
- W2017478720 creator A5025388780 @default.
- W2017478720 creator A5039853407 @default.
- W2017478720 date "2002-12-01" @default.
- W2017478720 modified "2023-10-03" @default.
- W2017478720 title "Low Revascularization of Experimentally Transplanted Human Pancreatic Islets" @default.
- W2017478720 cites W1591058727 @default.
- W2017478720 cites W1617468662 @default.
- W2017478720 cites W1948107809 @default.
- W2017478720 cites W1964100264 @default.
- W2017478720 cites W1968914550 @default.
- W2017478720 cites W1969366649 @default.
- W2017478720 cites W1978138910 @default.
- W2017478720 cites W2008701006 @default.
- W2017478720 cites W2010491087 @default.
- W2017478720 cites W2013863745 @default.
- W2017478720 cites W2016516613 @default.
- W2017478720 cites W2024598718 @default.
- W2017478720 cites W2024913180 @default.
- W2017478720 cites W2025033182 @default.
- W2017478720 cites W2025160371 @default.
- W2017478720 cites W2029243855 @default.
- W2017478720 cites W2039586163 @default.
- W2017478720 cites W2049117496 @default.
- W2017478720 cites W2049681765 @default.
- W2017478720 cites W2050355889 @default.
- W2017478720 cites W2051864726 @default.
- W2017478720 cites W2073130088 @default.
- W2017478720 cites W2079749800 @default.
- W2017478720 cites W2097877954 @default.
- W2017478720 cites W2102729708 @default.
- W2017478720 cites W2106710972 @default.
- W2017478720 cites W2112605972 @default.
- W2017478720 cites W2113922470 @default.
- W2017478720 cites W2117594247 @default.
- W2017478720 cites W2118859345 @default.
- W2017478720 cites W2135719441 @default.
- W2017478720 cites W2137315507 @default.
- W2017478720 cites W2146133225 @default.
- W2017478720 cites W2151845927 @default.
- W2017478720 cites W2158844203 @default.
- W2017478720 cites W2161757558 @default.
- W2017478720 cites W2276861852 @default.
- W2017478720 cites W2328786770 @default.
- W2017478720 cites W2413696750 @default.
- W2017478720 cites W397537768 @default.
- W2017478720 doi "https://doi.org/10.1210/jc.2002-020728" @default.
- W2017478720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12466329" @default.
- W2017478720 hasPublicationYear "2002" @default.
- W2017478720 type Work @default.
- W2017478720 sameAs 2017478720 @default.
- W2017478720 citedByCount "169" @default.
- W2017478720 countsByYear W20174787202012 @default.
- W2017478720 countsByYear W20174787202013 @default.
- W2017478720 countsByYear W20174787202014 @default.
- W2017478720 countsByYear W20174787202015 @default.
- W2017478720 countsByYear W20174787202016 @default.
- W2017478720 countsByYear W20174787202017 @default.
- W2017478720 countsByYear W20174787202018 @default.
- W2017478720 countsByYear W20174787202019 @default.
- W2017478720 countsByYear W20174787202020 @default.
- W2017478720 countsByYear W20174787202021 @default.
- W2017478720 countsByYear W20174787202022 @default.
- W2017478720 countsByYear W20174787202023 @default.
- W2017478720 crossrefType "journal-article" @default.
- W2017478720 hasAuthorship W2017478720A5019273811 @default.
- W2017478720 hasAuthorship W2017478720A5025388780 @default.
- W2017478720 hasAuthorship W2017478720A5039853407 @default.
- W2017478720 hasBestOaLocation W20174787201 @default.
- W2017478720 hasConcept C126322002 @default.
- W2017478720 hasConcept C134018914 @default.
- W2017478720 hasConcept C146957229 @default.
- W2017478720 hasConcept C158846371 @default.
- W2017478720 hasConcept C165220095 @default.
- W2017478720 hasConcept C16613235 @default.
- W2017478720 hasConcept C2779306644 @default.
- W2017478720 hasConcept C2779464278 @default.
- W2017478720 hasConcept C2779855799 @default.
- W2017478720 hasConcept C2911091166 @default.
- W2017478720 hasConcept C500558357 @default.
- W2017478720 hasConcept C71924100 @default.
- W2017478720 hasConceptScore W2017478720C126322002 @default.
- W2017478720 hasConceptScore W2017478720C134018914 @default.
- W2017478720 hasConceptScore W2017478720C146957229 @default.
- W2017478720 hasConceptScore W2017478720C158846371 @default.
- W2017478720 hasConceptScore W2017478720C165220095 @default.
- W2017478720 hasConceptScore W2017478720C16613235 @default.
- W2017478720 hasConceptScore W2017478720C2779306644 @default.
- W2017478720 hasConceptScore W2017478720C2779464278 @default.
- W2017478720 hasConceptScore W2017478720C2779855799 @default.
- W2017478720 hasConceptScore W2017478720C2911091166 @default.
- W2017478720 hasConceptScore W2017478720C500558357 @default.
- W2017478720 hasConceptScore W2017478720C71924100 @default.
- W2017478720 hasIssue "12" @default.
- W2017478720 hasLocation W20174787201 @default.
- W2017478720 hasLocation W20174787202 @default.