FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017481104> ?p ?o ?g. }

• W2017481104 endingPage "10493" @default.
• W2017481104 startingPage "10489" @default.
• W2017481104 abstract "The effects of dopamine-specific manipulations on neuropeptide gene expression in intrastriatal grafts of fetal striatal tissue were studied by quantitative in situ hybridization histochemistry, using 35S-labeled oligonucleotide probes. Messenger RNA transcripts for the striatal neuropeptides preproenkephalin (PPE) and preprotachykinin (PPT) were detected in neurons forming discrete patches in the striatal grafts. The relative abundance of PPE and PPT mRNA-expressing neurons within the graft patches (51-54%) was similar to that found in normal caudate-putamen. In specimens with intact dopamine afferents the expression of PPE mRNA in grafted neurons was similar to that found in normal caudate putamen, whereas the hybridization signal for PPT mRNA was 27% higher in the graft neurons than in the normal caudate-putamen. Removal of host dopaminergic afferents by 6-hydroxydopamine lesions of the ipsilateral mesostriatal dopamine pathway increased the hybridization signal for PPE mRNA both in the grafts (+84%) and in the spared ipsilateral host caudate-putamen (+125%), whereas the PPT signal was reduced by 53% in the grafts and by 51% in the remaining host caudate-putamen. Similarly, chronic treatment of grafted animals with the dopamine receptor antagonist haloperidol (2 mg/kg per day for 10 days) produced a 146% increase in the PPE signal in the grafts and a 175% increase in the intact contralateral caudate-putamen, whereas the signal for PPT mRNA was again decreased by 52% and 51% in the grafts and host caudate-putamen, respectively. These results show that the host nigrostriatal dopamine pathway differentially regulates enkephalin and substance P gene expression within striatal grafts and thereby exerts a tonic functional influence over grafted striatal neurons." @default.
• W2017481104 created "2016-06-24" @default.
• W2017481104 creator A5048838160 @default.
• W2017481104 creator A5052634957 @default.
• W2017481104 creator A5056950349 @default.
• W2017481104 date "1992-11-01" @default.
• W2017481104 modified "2023-10-03" @default.
• W2017481104 title "Differential regulation of neuropeptide mRNA expression in intrastriatal striatal transplants by host dopaminergic afferents." @default.
• W2017481104 cites W1857277871 @default.
• W2017481104 cites W1889572575 @default.
• W2017481104 cites W1917378969 @default.
• W2017481104 cites W1965007932 @default.
• W2017481104 cites W1966256648 @default.
• W2017481104 cites W1975229960 @default.
• W2017481104 cites W1978572562 @default.
• W2017481104 cites W1980435560 @default.
• W2017481104 cites W1986956130 @default.
• W2017481104 cites W1990839093 @default.
• W2017481104 cites W1998060288 @default.
• W2017481104 cites W1999961963 @default.
• W2017481104 cites W2003161954 @default.
• W2017481104 cites W2015063879 @default.
• W2017481104 cites W2015429872 @default.
• W2017481104 cites W2019512774 @default.
• W2017481104 cites W2019834805 @default.
• W2017481104 cites W2020439765 @default.
• W2017481104 cites W2021683549 @default.
• W2017481104 cites W2027691517 @default.
• W2017481104 cites W2035162334 @default.
• W2017481104 cites W2039732315 @default.
• W2017481104 cites W2042538904 @default.
• W2017481104 cites W2043859166 @default.
• W2017481104 cites W2047093858 @default.
• W2017481104 cites W2048646915 @default.
• W2017481104 cites W2048910236 @default.
• W2017481104 cites W2057176173 @default.
• W2017481104 cites W2070898934 @default.
• W2017481104 cites W2117593813 @default.
• W2017481104 cites W2149028947 @default.
• W2017481104 cites W2164158899 @default.
• W2017481104 cites W2168823834 @default.
• W2017481104 cites W2326829941 @default.
• W2017481104 doi "https://doi.org/10.1073/pnas.89.21.10489" @default.
• W2017481104 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/50364" @default.
• W2017481104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1438238" @default.
• W2017481104 hasPublicationYear "1992" @default.
• W2017481104 type Work @default.
• W2017481104 sameAs 2017481104 @default.
• W2017481104 citedByCount "33" @default.
• W2017481104 countsByYear W20174811042012 @default.
• W2017481104 countsByYear W20174811042014 @default.
• W2017481104 countsByYear W20174811042020 @default.
• W2017481104 countsByYear W20174811042022 @default.
• W2017481104 crossrefType "journal-article" @default.
• W2017481104 hasAuthorship W2017481104A5048838160 @default.
• W2017481104 hasAuthorship W2017481104A5052634957 @default.
• W2017481104 hasAuthorship W2017481104A5056950349 @default.
• W2017481104 hasBestOaLocation W20174811041 @default.
• W2017481104 hasConcept C104317684 @default.
• W2017481104 hasConcept C118303440 @default.
• W2017481104 hasConcept C126322002 @default.
• W2017481104 hasConcept C134018914 @default.
• W2017481104 hasConcept C137183658 @default.
• W2017481104 hasConcept C150194340 @default.
• W2017481104 hasConcept C170493617 @default.
• W2017481104 hasConcept C2777288102 @default.
• W2017481104 hasConcept C2777803847 @default.
• W2017481104 hasConcept C2779714222 @default.
• W2017481104 hasConcept C2780062018 @default.
• W2017481104 hasConcept C2780938664 @default.
• W2017481104 hasConcept C2781063702 @default.
• W2017481104 hasConcept C2781423529 @default.
• W2017481104 hasConcept C513476851 @default.
• W2017481104 hasConcept C55493867 @default.
• W2017481104 hasConcept C71924100 @default.
• W2017481104 hasConcept C81439078 @default.
• W2017481104 hasConcept C86803240 @default.
• W2017481104 hasConceptScore W2017481104C104317684 @default.
• W2017481104 hasConceptScore W2017481104C118303440 @default.
• W2017481104 hasConceptScore W2017481104C126322002 @default.
• W2017481104 hasConceptScore W2017481104C134018914 @default.
• W2017481104 hasConceptScore W2017481104C137183658 @default.
• W2017481104 hasConceptScore W2017481104C150194340 @default.
• W2017481104 hasConceptScore W2017481104C170493617 @default.
• W2017481104 hasConceptScore W2017481104C2777288102 @default.
• W2017481104 hasConceptScore W2017481104C2777803847 @default.
• W2017481104 hasConceptScore W2017481104C2779714222 @default.
• W2017481104 hasConceptScore W2017481104C2780062018 @default.
• W2017481104 hasConceptScore W2017481104C2780938664 @default.
• W2017481104 hasConceptScore W2017481104C2781063702 @default.
• W2017481104 hasConceptScore W2017481104C2781423529 @default.
• W2017481104 hasConceptScore W2017481104C513476851 @default.
• W2017481104 hasConceptScore W2017481104C55493867 @default.
• W2017481104 hasConceptScore W2017481104C71924100 @default.
• W2017481104 hasConceptScore W2017481104C81439078 @default.
• W2017481104 hasConceptScore W2017481104C86803240 @default.
• W2017481104 hasIssue "21" @default.
• W2017481104 hasLocation W20174811041 @default.

• next