Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017482008> ?p ?o ?g. }
- W2017482008 endingPage "142" @default.
- W2017482008 startingPage "139" @default.
- W2017482008 abstract "Background Psoriasis is a common immune-mediated inflammatory skin disease with strong genetic dispositions. Although more than 40 susceptibility loci have been revealed mostly through psoriasis genome wide association studies, genetic variants with small effect remain to be identified. Objective In order to explore the susceptibility genes with potential regulatory function, we queried jointly two psoriasis genome wide association cohorts and an expression dataset. Methods We integrated conventional genome-wide association evidences in 2326 Han Chinese and 2719 Caucasian populations, and the signature of expression quantitative trait loci (eQTL) in lymphoblastoid B cells, with application of Bayesian algorithm. Results Five genes with implied regulatory effect were revealed to be associated significantly with the risk of psoriasis, with one novel signal in FAM20B gene which is significantly expressed (P = 3.24 × 10−5). Besides, seven single nucleotide polymorphisms were identified to be involved in the mechanism of psoriasis through eQTL effect. Conclusions We identified FAM20B as a risk regulatory gene in the etiology of psoriasis at first time. This study shed a spotlight on the immune regulatory mechanism in psoriasis." @default.
- W2017482008 created "2016-06-24" @default.
- W2017482008 creator A5001699296 @default.
- W2017482008 creator A5012350468 @default.
- W2017482008 creator A5012436877 @default.
- W2017482008 creator A5027749624 @default.
- W2017482008 creator A5027902249 @default.
- W2017482008 creator A5029277354 @default.
- W2017482008 creator A5036454981 @default.
- W2017482008 creator A5043143120 @default.
- W2017482008 creator A5064660745 @default.
- W2017482008 creator A5073686044 @default.
- W2017482008 creator A5084727740 @default.
- W2017482008 creator A5087838135 @default.
- W2017482008 date "2014-11-01" @default.
- W2017482008 modified "2023-09-22" @default.
- W2017482008 title "Five regulatory genes detected by matching signatures of eQTL and GWAS in psoriasis" @default.
- W2017482008 cites W1727561536 @default.
- W2017482008 cites W1972332916 @default.
- W2017482008 cites W1976113574 @default.
- W2017482008 cites W1980991473 @default.
- W2017482008 cites W1981924240 @default.
- W2017482008 cites W1982546670 @default.
- W2017482008 cites W2007062398 @default.
- W2017482008 cites W2022259919 @default.
- W2017482008 cites W2029292942 @default.
- W2017482008 cites W2033151532 @default.
- W2017482008 cites W2044077896 @default.
- W2017482008 cites W2045113343 @default.
- W2017482008 cites W2046579032 @default.
- W2017482008 cites W2067813923 @default.
- W2017482008 cites W2090092127 @default.
- W2017482008 cites W2102889851 @default.
- W2017482008 cites W2110269506 @default.
- W2017482008 cites W2118448966 @default.
- W2017482008 cites W2126510876 @default.
- W2017482008 cites W2127526802 @default.
- W2017482008 cites W2132041082 @default.
- W2017482008 cites W2132800651 @default.
- W2017482008 cites W2143625465 @default.
- W2017482008 cites W2148269820 @default.
- W2017482008 cites W2152224204 @default.
- W2017482008 cites W2159930535 @default.
- W2017482008 cites W2162276444 @default.
- W2017482008 cites W2170129323 @default.
- W2017482008 cites W2171698295 @default.
- W2017482008 cites W2259938310 @default.
- W2017482008 cites W2561759163 @default.
- W2017482008 cites W4242920965 @default.
- W2017482008 doi "https://doi.org/10.1016/j.jdermsci.2014.07.007" @default.
- W2017482008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25205356" @default.
- W2017482008 hasPublicationYear "2014" @default.
- W2017482008 type Work @default.
- W2017482008 sameAs 2017482008 @default.
- W2017482008 citedByCount "9" @default.
- W2017482008 countsByYear W20174820082015 @default.
- W2017482008 countsByYear W20174820082016 @default.
- W2017482008 countsByYear W20174820082017 @default.
- W2017482008 countsByYear W20174820082019 @default.
- W2017482008 countsByYear W20174820082020 @default.
- W2017482008 countsByYear W20174820082021 @default.
- W2017482008 countsByYear W20174820082022 @default.
- W2017482008 crossrefType "journal-article" @default.
- W2017482008 hasAuthorship W2017482008A5001699296 @default.
- W2017482008 hasAuthorship W2017482008A5012350468 @default.
- W2017482008 hasAuthorship W2017482008A5012436877 @default.
- W2017482008 hasAuthorship W2017482008A5027749624 @default.
- W2017482008 hasAuthorship W2017482008A5027902249 @default.
- W2017482008 hasAuthorship W2017482008A5029277354 @default.
- W2017482008 hasAuthorship W2017482008A5036454981 @default.
- W2017482008 hasAuthorship W2017482008A5043143120 @default.
- W2017482008 hasAuthorship W2017482008A5064660745 @default.
- W2017482008 hasAuthorship W2017482008A5073686044 @default.
- W2017482008 hasAuthorship W2017482008A5084727740 @default.
- W2017482008 hasAuthorship W2017482008A5087838135 @default.
- W2017482008 hasConcept C104317684 @default.
- W2017482008 hasConcept C106208931 @default.
- W2017482008 hasConcept C135763542 @default.
- W2017482008 hasConcept C153209595 @default.
- W2017482008 hasConcept C168393362 @default.
- W2017482008 hasConcept C186413461 @default.
- W2017482008 hasConcept C203014093 @default.
- W2017482008 hasConcept C2780564577 @default.
- W2017482008 hasConcept C54355233 @default.
- W2017482008 hasConcept C70721500 @default.
- W2017482008 hasConcept C86803240 @default.
- W2017482008 hasConceptScore W2017482008C104317684 @default.
- W2017482008 hasConceptScore W2017482008C106208931 @default.
- W2017482008 hasConceptScore W2017482008C135763542 @default.
- W2017482008 hasConceptScore W2017482008C153209595 @default.
- W2017482008 hasConceptScore W2017482008C168393362 @default.
- W2017482008 hasConceptScore W2017482008C186413461 @default.
- W2017482008 hasConceptScore W2017482008C203014093 @default.
- W2017482008 hasConceptScore W2017482008C2780564577 @default.
- W2017482008 hasConceptScore W2017482008C54355233 @default.
- W2017482008 hasConceptScore W2017482008C70721500 @default.
- W2017482008 hasConceptScore W2017482008C86803240 @default.
- W2017482008 hasFunder F4320322725 @default.