FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017482142> ?p ?o ?g. }

• W2017482142 endingPage "221" @default.
• W2017482142 startingPage "A" @default.
• W2017482142 abstract "Background: Visceral hypersensitivity, altered gastrointestinal motility and secretion, and psychosocial factors are considered to be of great importance for the symptom pattern in irritable bowel syndrome (IBS). The Rome III criteria propose subtyping of IBS patients based on stool form alone (Longstreth et al Gastroenterology 2006), but the association with the underlying pathophysiology is unknown. Aim: To evaluate the link between pathophysiological factors and Rome III subtyping. Methods: We included 129 IBS patients (96 females, 33 males; mean age 37 (19-67) years). The patients were subtyped according to the Rome III criteria based on one-week diaries, where the stool form (Bristol Stool Form scale) was reported. All patients underwent investigations to assess colonic motility (colonic transit time), small intestinal motility and secretion (antroduodenojejunal manometry with jejunal transmural potential difference (PD) measurement) and rectal sensorimotor function (rectal balloon distensions before and after meal intake). The patients also completed questionnaires to assess the severity of psychological, gastrointestinal and extraintestinal symptoms. Results: Fifty-five patients had IBS-D (diarrhea), 29 IBS-C (constipation), 11 IBS-M (mixed) and 34 IBS-U (unsubtyped). For the analyses M+U was combined into one group (“NonCNonD”). Colonic transit time differed between the subgroups (p<0.0001), with slower transit in IBS-C (1.8±2.9 (mean±SD) days), faster in IBS-D (1.0±1.4 days), and intermediate in the NonCNonD-group (1.4±2.0 days). There were also group differences in small intestinal motility, with higher contraction frequency in the fasted state (p<0.05), longer phase III duration (p<0.01) and faster propagation velocity of phase III (p<0.01) in IBS-D. The small intestinal secretion during phase III (mean PD × length of the secreting segment, calculated from duration and propagation velocity) also differed between the subtypes, with enhanced secretion in IBS-D (p<0.001). Also the mean fasted PD tended to be higher in IBS-D (p<0.05). Rectal sensitivity, compliance and the rectal tone response, as well as psychological or extraintestinal symptom severity was similar in the subtypes. The perceived severity of constipation (p<0.01) and diarrhea (p<0.01), but not other GI symptoms, also differed between the subtypes. Conclusion: Subtyping of IBS patients based on the stool form is associated with alterations small intestinal and colonic motility, as well as small intestinal secretion. However, other pathophysiological factors, as well as symptoms other than constipation and diarrhea, seem unrelated to the different Rome III-based IBS subtypes." @default.
• W2017482142 created "2016-06-24" @default.
• W2017482142 creator A5006402971 @default.
• W2017482142 creator A5007674070 @default.
• W2017482142 creator A5020352763 @default.
• W2017482142 creator A5045103784 @default.
• W2017482142 creator A5087162630 @default.
• W2017482142 creator A5088122979 @default.
• W2017482142 date "2009-05-01" @default.
• W2017482142 modified "2023-10-14" @default.
• W2017482142 title "S1245 ROME III Subtyping Is Associated with Alterations in Intestinal Motility and Secretion, But Not with Sensitivity or Psychosocial Factors" @default.
• W2017482142 doi "https://doi.org/10.1016/s0016-5085(09)60994-x" @default.
• W2017482142 hasPublicationYear "2009" @default.
• W2017482142 type Work @default.
• W2017482142 sameAs 2017482142 @default.
• W2017482142 citedByCount "1" @default.
• W2017482142 crossrefType "journal-article" @default.
• W2017482142 hasAuthorship W2017482142A5006402971 @default.
• W2017482142 hasAuthorship W2017482142A5007674070 @default.
• W2017482142 hasAuthorship W2017482142A5020352763 @default.
• W2017482142 hasAuthorship W2017482142A5045103784 @default.
• W2017482142 hasAuthorship W2017482142A5087162630 @default.
• W2017482142 hasAuthorship W2017482142A5088122979 @default.
• W2017482142 hasConcept C118552586 @default.
• W2017482142 hasConcept C126322002 @default.
• W2017482142 hasConcept C127413603 @default.
• W2017482142 hasConcept C150966472 @default.
• W2017482142 hasConcept C199360897 @default.
• W2017482142 hasConcept C21200559 @default.
• W2017482142 hasConcept C24326235 @default.
• W2017482142 hasConcept C41008148 @default.
• W2017482142 hasConcept C49039625 @default.
• W2017482142 hasConcept C58207958 @default.
• W2017482142 hasConcept C71924100 @default.
• W2017482142 hasConcept C83852419 @default.
• W2017482142 hasConcept C86803240 @default.
• W2017482142 hasConcept C95444343 @default.
• W2017482142 hasConceptScore W2017482142C118552586 @default.
• W2017482142 hasConceptScore W2017482142C126322002 @default.
• W2017482142 hasConceptScore W2017482142C127413603 @default.
• W2017482142 hasConceptScore W2017482142C150966472 @default.
• W2017482142 hasConceptScore W2017482142C199360897 @default.
• W2017482142 hasConceptScore W2017482142C21200559 @default.
• W2017482142 hasConceptScore W2017482142C24326235 @default.
• W2017482142 hasConceptScore W2017482142C41008148 @default.
• W2017482142 hasConceptScore W2017482142C49039625 @default.
• W2017482142 hasConceptScore W2017482142C58207958 @default.
• W2017482142 hasConceptScore W2017482142C71924100 @default.
• W2017482142 hasConceptScore W2017482142C83852419 @default.
• W2017482142 hasConceptScore W2017482142C86803240 @default.
• W2017482142 hasConceptScore W2017482142C95444343 @default.
• W2017482142 hasIssue "5" @default.
• W2017482142 hasLocation W20174821421 @default.
• W2017482142 hasOpenAccess W2017482142 @default.
• W2017482142 hasPrimaryLocation W20174821421 @default.
• W2017482142 hasRelatedWork W2020884724 @default.
• W2017482142 hasRelatedWork W2085048026 @default.
• W2017482142 hasRelatedWork W2114259434 @default.
• W2017482142 hasRelatedWork W2159390875 @default.
• W2017482142 hasRelatedWork W2161296685 @default.
• W2017482142 hasRelatedWork W2189005594 @default.
• W2017482142 hasRelatedWork W2278234310 @default.
• W2017482142 hasRelatedWork W2767280586 @default.
• W2017482142 hasRelatedWork W3122956057 @default.
• W2017482142 hasRelatedWork W3196995010 @default.
• W2017482142 hasVolume "136" @default.
• W2017482142 isParatext "false" @default.
• W2017482142 isRetracted "false" @default.
• W2017482142 magId "2017482142" @default.
• W2017482142 workType "article" @default.