Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017484407> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2017484407 endingPage "267" @default.
- W2017484407 startingPage "259" @default.
- W2017484407 abstract "The mammary cells in virgin mice are essentially non-proliferative, but they can be induced to undergo DNA synthesis in vitro in the presence of insulin. Time course studies on polyamine biosynthesis and DNA synthesis showed that insulin elicits sequential stimulation of the activity of the polyamine biosynthetic enzymes, ornithine decarboxylase, S-adenosyl-L-methionine decarboxylase (SAMDC) and spermidine synthase, and an increase in the concentration of spermidine prior to the augmentation of DNA synthesis. At 48 to 72 hours of culture when DNA synthesis is maximal, the concentration of spermidine increased 2− to 3-fold, whereas the level of spermine remained unchanged. Addition of methyl glyoxal bis(guanylhydrazone) (5—10 μM), a potent inhibitor of SAMDC, to the medium at the onset of culture resulted in inhibition of spermidine formation and DNA synthesis, but when added at 24 hours or 48 hours of culture, the inhibitory effect on DNA synthesis was greatly reduced. The drug, however, produced little inhibition of RNA and protein synthesis. Inhibition of DNA synthesis by the drug can be reversed by addition of spermidine or other polyamines such as putrescine, cadaverine and spermine to the culture. Spermidine is, however, the only polyamine that is effective at physiological concentrations (100∼150 pmoles/mg tissue). These results suggest a possibility that spermidine may play a key role in the regulation of mammary cell proliferation." @default.
- W2017484407 created "2016-06-24" @default.
- W2017484407 creator A5003943272 @default.
- W2017484407 creator A5068704402 @default.
- W2017484407 creator A5083887794 @default.
- W2017484407 date "1978-06-01" @default.
- W2017484407 modified "2023-10-14" @default.
- W2017484407 title "Polyamine biosynthesis and DNA synthesis in cultured mammary gland explants from virgin mice" @default.
- W2017484407 cites W1493996129 @default.
- W2017484407 cites W1514505265 @default.
- W2017484407 cites W1591957236 @default.
- W2017484407 cites W1918421567 @default.
- W2017484407 cites W1964432327 @default.
- W2017484407 cites W1971026803 @default.
- W2017484407 cites W1977778645 @default.
- W2017484407 cites W1979132535 @default.
- W2017484407 cites W1979909001 @default.
- W2017484407 cites W1994749318 @default.
- W2017484407 cites W200090344 @default.
- W2017484407 cites W2015923256 @default.
- W2017484407 cites W2026912546 @default.
- W2017484407 cites W2044163321 @default.
- W2017484407 cites W2071489383 @default.
- W2017484407 cites W2074754198 @default.
- W2017484407 cites W2091729696 @default.
- W2017484407 cites W2093207465 @default.
- W2017484407 cites W2115713071 @default.
- W2017484407 cites W2124217844 @default.
- W2017484407 cites W2345902112 @default.
- W2017484407 doi "https://doi.org/10.1002/jcp.1040950303" @default.
- W2017484407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/565785" @default.
- W2017484407 hasPublicationYear "1978" @default.
- W2017484407 type Work @default.
- W2017484407 sameAs 2017484407 @default.
- W2017484407 citedByCount "24" @default.
- W2017484407 crossrefType "journal-article" @default.
- W2017484407 hasAuthorship W2017484407A5003943272 @default.
- W2017484407 hasAuthorship W2017484407A5068704402 @default.
- W2017484407 hasAuthorship W2017484407A5083887794 @default.
- W2017484407 hasConcept C121289238 @default.
- W2017484407 hasConcept C153911025 @default.
- W2017484407 hasConcept C181199279 @default.
- W2017484407 hasConcept C2776109719 @default.
- W2017484407 hasConcept C2777167505 @default.
- W2017484407 hasConcept C2777497464 @default.
- W2017484407 hasConcept C2780115381 @default.
- W2017484407 hasConcept C552990157 @default.
- W2017484407 hasConcept C553450214 @default.
- W2017484407 hasConcept C55493867 @default.
- W2017484407 hasConcept C64241487 @default.
- W2017484407 hasConcept C86803240 @default.
- W2017484407 hasConceptScore W2017484407C121289238 @default.
- W2017484407 hasConceptScore W2017484407C153911025 @default.
- W2017484407 hasConceptScore W2017484407C181199279 @default.
- W2017484407 hasConceptScore W2017484407C2776109719 @default.
- W2017484407 hasConceptScore W2017484407C2777167505 @default.
- W2017484407 hasConceptScore W2017484407C2777497464 @default.
- W2017484407 hasConceptScore W2017484407C2780115381 @default.
- W2017484407 hasConceptScore W2017484407C552990157 @default.
- W2017484407 hasConceptScore W2017484407C553450214 @default.
- W2017484407 hasConceptScore W2017484407C55493867 @default.
- W2017484407 hasConceptScore W2017484407C64241487 @default.
- W2017484407 hasConceptScore W2017484407C86803240 @default.
- W2017484407 hasIssue "3" @default.
- W2017484407 hasLocation W20174844071 @default.
- W2017484407 hasLocation W20174844072 @default.
- W2017484407 hasOpenAccess W2017484407 @default.
- W2017484407 hasPrimaryLocation W20174844071 @default.
- W2017484407 hasRelatedWork W1494632330 @default.
- W2017484407 hasRelatedWork W1892225957 @default.
- W2017484407 hasRelatedWork W1968714063 @default.
- W2017484407 hasRelatedWork W1976211275 @default.
- W2017484407 hasRelatedWork W2006999137 @default.
- W2017484407 hasRelatedWork W2083729530 @default.
- W2017484407 hasRelatedWork W2414326766 @default.
- W2017484407 hasRelatedWork W2460194077 @default.
- W2017484407 hasRelatedWork W24866247 @default.
- W2017484407 hasRelatedWork W68899216 @default.
- W2017484407 hasVolume "95" @default.
- W2017484407 isParatext "false" @default.
- W2017484407 isRetracted "false" @default.
- W2017484407 magId "2017484407" @default.
- W2017484407 workType "article" @default.