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• W2017485612 abstract "Purpose. To understand the role of polymorphisms in the LEP (rs7799039 and rs2167270) and LEPR (rs1137101 and rs1137100) genes in DTC susceptibility and their effect on leptin levels. Methods. We studied 153 patients with DTC and 234 controls through TaqMan SNP Genotyping and ELISA, comparing these data to the clinicopathological data of patients with DTC. Results. Patients with AA genotype of rs7799039 had higher levels of serum leptin (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mn>9.22</mml:mn><mml:mo>±</mml:mo><mml:mn>0.98</mml:mn></mml:math> ng/mL) than those with AG genotype (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mn>10.07</mml:mn><mml:mo>±</mml:mo><mml:mn>0.60</mml:mn></mml:math> ng/mL;<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.005</mml:mn></mml:math>). Individuals with AG genotype of rs2167270 also produced higher serum leptin levels (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mn>10.05</mml:mn><mml:mo>±</mml:mo><mml:mn>0.59</mml:mn></mml:math> ng/mL) than the subjects with GG genotype (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mn>9.52</mml:mn><mml:mo>±</mml:mo><mml:mn>0.79</mml:mn></mml:math> ng/mL;<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:math>). A multivariate logistic regression adjusted for gender, age, and BMI showed that the AG genotype of rs7799039 was an independent risk for DTC (OR, 11.689;<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.0183</mml:mn></mml:math>; 95% CI, 1.516–90.119). Similarly, AG and GG genotypes of rs1137101 increased the susceptibility to DTC (OR, 3.747;<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.027</mml:mn></mml:math>; 95% CI, 1.161–12.092 and OR, 5.437;<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M9><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.013</mml:mn></mml:math>; 95% CI, 1.426–20.729). Conclusions. We demonstrated that rs7799039 and rs2167270 polymorphisms modify the serum leptin concentrations in patients with DTC. Furthermore, polymorphisms rs7799039 and rs1137101 increase the risk of DTC development, although they do not correlate with tumor aggressiveness." @default.
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• W2017485612 date "2015-01-01" @default.
• W2017485612 modified "2023-10-18" @default.
• W2017485612 title "Polymorphism in<i>LEP</i>and<i>LEPR</i>May Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer" @default.
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• W2017485612 doi "https://doi.org/10.1155/2015/173218" @default.
• W2017485612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4355553" @default.
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