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• W2017485835 abstract "We have examined the relationship between Inc 7-M plasmids conferring resistance to gentamicin by synthesis of an acetylating enzyme (AAC(3)) and other plasmids of the same incompatibility group by agarose gel electrophoresis following digestion with restriction endonucleases and by nucleic acid hybridization. Although isolated from different bacterial hosts over a 6-year period of time the three plasmids mediating acetylation of gentamicin are very similar. They are related to, but distinct from the other Inc 7-M plasmids. The in vivo evolution of these plasmids appeared modular, involving sequential deletions and stepwise acquisition of transposons (Tn6, Tn7, and a Tn9-like element). These results are in favor of a plasmid epidemic and indicate a great stability of the transfer factor part of these plasmids under natural conditions." @default.
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• W2017485835 date "1982-11-01" @default.
• W2017485835 modified "2023-09-25" @default.
• W2017485835 title "Modular evolution of disseminated Inc 7-M plasmids encoding gentamicin resistance" @default.
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• W2017485835 doi "https://doi.org/10.1016/0147-619x(82)90060-9" @default.
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