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- W2017486564 abstract "Despite the fact that alcohol is one of the most widely used and abused of all psychoactive drugs, there is surprising lack of consensus on the molecular mechanisms of action. One particularly important aspect of ethanol (EtOH) is its effect on the reward system in the mammalian brain, because it may help us to understand and help people afflicted with alcohol abuse and addiction better. In PNAS, Patricia Janak, Dorit Ron, and their colleagues (1) at the Ernest Gallo Clinic and Research Center associated with the University of California, San Francisco, are making progress on both aspects by using the technique of viral-mediated RNAi to knock down the expression of a specific inhibitory neurotransmitter receptor protein implicated in low- to moderate-dose EtOH effects on brain. This manipulation was carried out in vivo on rats in a specific mesolimbic brain region implicated in the reinforcing effects of EtOH, producing a significant reduction in oral uptake of EtOH." @default.
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- W2017486564 title "Extrasynaptic GABA <sub>A</sub> receptors in the nucleus accumbens are necessary for alcohol drinking" @default.
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- W2017486564 doi "https://doi.org/10.1073/pnas.1102818108" @default.
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