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- W2017487423 abstract "Abstract The results of a pilot study to determine whether heparin-impregnated cloth-covered cardiac valves may offer increased protection against thromboembolism are reported. In animal studies the heparin-impregnated valves in the tricuspid position were encapsulated within 3 months by a thin, smooth, uniform neointima. In contrast, the control valves had a nodular accumulation of tissue with a thickness of 1 to 2 mm. In a clinical evaluation, 32 patients were managed in a standard fashion postoperatively with orally administered anticoagulants (Group 1) while 34 patients were given heparin-impregnated valves (Group 2). Six of the 32 patients in Group 1 had a cerebral embolic episode. In contrast, the Group 2 patients, without systemic anticoagulation, had a lower incidence of cerebral embolism (2 of 34). The use of heparin-impregnated cloth-covered valves without systemic anticoagulation did not increase the incidence of thromboembolism, and it may reduce the potential complications of anticoagulant therapy." @default.
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- W2017487423 date "1974-04-01" @default.
- W2017487423 modified "2023-09-27" @default.
- W2017487423 title "Experimental and Clinical Evaluation of Heparin-Impregnated Cloth-Covered Cardiac Valves Used Without Systemic Anticoagulation" @default.
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- W2017487423 doi "https://doi.org/10.1016/s0003-4975(10)65663-9" @default.
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