FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017490061> ?p ?o ?g. }

• W2017490061 endingPage "100" @default.
• W2017490061 startingPage "93" @default.
• W2017490061 abstract "Combining anti-angiogenesis agents with cytotoxic agents for the treatment of malignant gliomas may affect the cytotoxic drug distribution by normalizing the blood–brain barrier (BBB). This study examines the intratumoral concentration of temozolomide (TMZ) in the presence and absence of the pan-VEGF receptor tyrosine kinase inhibitor, cediranib. Seven nude rats bearing U87 intracerebral gliomas had a microdialysis probe centered within the tumor. Ten-days after tumor implantation, TMZ (50 mg/kg) was given orally. The extracellular fluid (ECF) concentrations of TMZ within the tumor were assessed via microdialysis for 6 h following TMZ administration. Cediranib (6 mg/kg) was then given orally, and 12 h later, TMZ was re-administered with subsequent microdialysis collection. A subset of animals also underwent functional MRI to assess angiogenesis in vivo at post-inoculation days 12 and 21, before and after the cediranib treatment. After dosing of oral TMZ only, ECF-TMZ mean-C max and area under the concentration curve(AUC0–∞) within the tumor were 0.59 μg/mL and 1.82 μg h/mL, respectively. Post-cediranib, ECF-TMZ mean-C max and AUC0–∞ were 0.83 μg/mL and 3.72 ± 0.61 μg h/mL within the tumor, respectively. This represented a 1.4-fold (p = 0.3) and 2.0-fold (p = 0.06) increase in the ECF-TMZ C max and AUC0–∞, respectively, after cediranib administration. In vivo MRI measurements of the various vascular parameters were consistent with a BBB “normalization” profile following cediranib treatment. In the U87 intracerebral glioma model, within the first day of administration of cediranib, the intratumoral concentrations of TMZ in tumor ECF were slightly, but not statistically significantly, increased when compared to the treatment of TMZ alone with radiographic evidence of a normalized BBB." @default.
• W2017490061 created "2016-06-24" @default.
• W2017490061 creator A5010219978 @default.
• W2017490061 creator A5015341987 @default.
• W2017490061 creator A5022565141 @default.
• W2017490061 creator A5037279124 @default.
• W2017490061 creator A5049334243 @default.
• W2017490061 creator A5051287778 @default.
• W2017490061 creator A5063671599 @default.
• W2017490061 creator A5065593135 @default.
• W2017490061 creator A5073314607 @default.
• W2017490061 date "2013-05-07" @default.
• W2017490061 modified "2023-09-25" @default.
• W2017490061 title "Microdialysis measurement of intratumoral temozolomide concentration after cediranib, a pan-VEGF receptor tyrosine kinase inhibitor, in a U87 glioma model" @default.
• W2017490061 cites W1570195799 @default.
• W2017490061 cites W1965642226 @default.
• W2017490061 cites W1968009184 @default.
• W2017490061 cites W1971835091 @default.
• W2017490061 cites W2005698053 @default.
• W2017490061 cites W2010993787 @default.
• W2017490061 cites W2017847341 @default.
• W2017490061 cites W2035907385 @default.
• W2017490061 cites W2043828718 @default.
• W2017490061 cites W2045717656 @default.
• W2017490061 cites W2096287682 @default.
• W2017490061 cites W2097373408 @default.
• W2017490061 cites W2121812224 @default.
• W2017490061 cites W2122788909 @default.
• W2017490061 cites W2128687105 @default.
• W2017490061 cites W2132697290 @default.
• W2017490061 cites W2134466068 @default.
• W2017490061 cites W2142104626 @default.
• W2017490061 cites W2146657519 @default.
• W2017490061 cites W2147535764 @default.
• W2017490061 cites W2162965771 @default.
• W2017490061 cites W2170367762 @default.
• W2017490061 cites W2502670554 @default.
• W2017490061 doi "https://doi.org/10.1007/s00280-013-2172-3" @default.
• W2017490061 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4596243" @default.
• W2017490061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23649683" @default.
• W2017490061 hasPublicationYear "2013" @default.
• W2017490061 type Work @default.
• W2017490061 sameAs 2017490061 @default.
• W2017490061 citedByCount "16" @default.
• W2017490061 countsByYear W20174900612013 @default.
• W2017490061 countsByYear W20174900612014 @default.
• W2017490061 countsByYear W20174900612015 @default.
• W2017490061 countsByYear W20174900612016 @default.
• W2017490061 countsByYear W20174900612018 @default.
• W2017490061 countsByYear W20174900612019 @default.
• W2017490061 countsByYear W20174900612020 @default.
• W2017490061 countsByYear W20174900612021 @default.
• W2017490061 countsByYear W20174900612022 @default.
• W2017490061 countsByYear W20174900612023 @default.
• W2017490061 crossrefType "journal-article" @default.
• W2017490061 hasAuthorship W2017490061A5010219978 @default.
• W2017490061 hasAuthorship W2017490061A5015341987 @default.
• W2017490061 hasAuthorship W2017490061A5022565141 @default.
• W2017490061 hasAuthorship W2017490061A5037279124 @default.
• W2017490061 hasAuthorship W2017490061A5049334243 @default.
• W2017490061 hasAuthorship W2017490061A5051287778 @default.
• W2017490061 hasAuthorship W2017490061A5063671599 @default.
• W2017490061 hasAuthorship W2017490061A5065593135 @default.
• W2017490061 hasAuthorship W2017490061A5073314607 @default.
• W2017490061 hasBestOaLocation W20174900612 @default.
• W2017490061 hasConcept C121608353 @default.
• W2017490061 hasConcept C126322002 @default.
• W2017490061 hasConcept C150903083 @default.
• W2017490061 hasConcept C185592680 @default.
• W2017490061 hasConcept C207001950 @default.
• W2017490061 hasConcept C2777389519 @default.
• W2017490061 hasConcept C2778227246 @default.
• W2017490061 hasConcept C2778820342 @default.
• W2017490061 hasConcept C50156730 @default.
• W2017490061 hasConcept C502942594 @default.
• W2017490061 hasConcept C529278444 @default.
• W2017490061 hasConcept C71924100 @default.
• W2017490061 hasConcept C86803240 @default.
• W2017490061 hasConcept C98274493 @default.
• W2017490061 hasConceptScore W2017490061C121608353 @default.
• W2017490061 hasConceptScore W2017490061C126322002 @default.
• W2017490061 hasConceptScore W2017490061C150903083 @default.
• W2017490061 hasConceptScore W2017490061C185592680 @default.
• W2017490061 hasConceptScore W2017490061C207001950 @default.
• W2017490061 hasConceptScore W2017490061C2777389519 @default.
• W2017490061 hasConceptScore W2017490061C2778227246 @default.
• W2017490061 hasConceptScore W2017490061C2778820342 @default.
• W2017490061 hasConceptScore W2017490061C50156730 @default.
• W2017490061 hasConceptScore W2017490061C502942594 @default.
• W2017490061 hasConceptScore W2017490061C529278444 @default.
• W2017490061 hasConceptScore W2017490061C71924100 @default.
• W2017490061 hasConceptScore W2017490061C86803240 @default.
• W2017490061 hasConceptScore W2017490061C98274493 @default.
• W2017490061 hasIssue "1" @default.
• W2017490061 hasLocation W20174900611 @default.
• W2017490061 hasLocation W20174900612 @default.
• W2017490061 hasLocation W20174900613 @default.
• W2017490061 hasLocation W20174900614 @default.

• next