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- W2017490384 abstract "The sensitivity of the (Na+ + K+)-ATPase to inhibition by Ca was increased 30-fold by a partially purified extract of human red cell hemolysate. The hemolysate fraction reduced the concentration of free Ca required for 50% inhibition from 30 microM to approx. 1 microM. Ca-dependent inhibition of the (Na+ + K+)-ATPase in the presence and absence of the hemolysate fraction was completely reversible. The hemolysate fraction also stimulated the Ca2+-ATPase and increased its affinity for Ca. In the presence of the hemolysate fraction, the concentration of free Ca that inhibited the (Na+ + K+)-ATPase by 50% was similar to that which half-maximally stimulated the Ca2+-ATPase. Boiling the fraction destoryed its effect on the (Na+ + K+)-ATPase, but did not impair its stimulation of the Ca2+-ATPase." @default.
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- W2017490384 date "1985-03-01" @default.
- W2017490384 modified "2023-09-26" @default.
- W2017490384 title "Sensitivity and reversibility of Ca-dependent inhibition of the (Na+ + K+)-ATPase of human red blood cells" @default.
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- W2017490384 doi "https://doi.org/10.1016/0005-2736(85)90243-3" @default.
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