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• W2017491610 abstract "Objectives: The aim of our work was to evaluate digital x-ray radiogrammetry (DXR) for the quantification of disease-related periarticular demineralization and computerized analysis of joint space distances (JSDA) for the measurement of joint space narrowing as a new diagnostic method for the early detection of joint-associated alterations and for monitoring disease progression in patients with rheumatoid arthritis (RA). Materials and Methods: Digital radiographs in 313 patients with varying severity of RA were performed annually and assessed by 2 radiologists using modified Larsen and also the Sharp scores within an observation period of 3 years. The hand radiographs underwent measurements of bone mineral density (BMD) and metacarpal index (MCI) by DXR, as well as computerized JSDA at the metacarpal-phalangeal articulation (JSD-MCP) for a cross-sectional and longitudinal study design. Results: Both DXR-BMD (−29.6%; P < 0.01) and DXR-MCI (−31.0%; P < 0.01) revealed a notable reduction dependent on the severity of RA (from grade 1 to grade 5 of the modified Larsen score); the severity dependent decrease of mean JSD-MCP ranged from –31.9% (P < 0.01; Sharp erosion part) to −39.1% (P < 0.01) for the modified Larsen score. Over an observation period of 3 years, a significant decrease of DXR-BMD (−22.3%) and DXR-MCI (−23.3%) as well as JSD-MCP mean (−17.5%) was observed (P < 0.05), whereas an accentuated decline of DXR and JSDA parameters was verified for patients without disease-modifying antirheumatic drugs or methotrexate therapy. Conclusion: Computerized analysis of hand radiographs by DXR and JSDA is a promising approach to assess the severity and to monitor the progression of RA because DXR and JSDA are timely able to measure periarticular demineralization and also narrowing of JSD-MCP dependent on the severity, the medical treatment and the course of RA." @default.
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• W2017491610 date "2006-01-01" @default.
• W2017491610 modified "2023-10-17" @default.
• W2017491610 title "Computerized Quantification of Joint Space Narrowing and Periarticular Demineralization in Patients With Rheumatoid Arthritis Based on Digital X-Ray Radiogrammetry" @default.
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• W2017491610 doi "https://doi.org/10.1097/01.rli.0000191594.76235.a0" @default.
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