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- W2017496941 abstract "γδ T cells expressing Vγ2Vδ2 T cell receptors are activated by a broad range of phosphorus-containing small molecules, termed phosphoantigens, and are of interest in the context of the chemotherapy of B cell malignancies. Here, we report the synthesis of four pairs of chiral phosphoantigens: the bromohydrins of isopentenyl diphosphate (Phosphostim™), the epoxides of isopentenyl diphosphate (EIPP); and the corresponding bromohydrin and epoxide analogs of but-3-enyl diphosphate. The ability of each compound to stimulate human Vγ2Vδ2 T cells was determined by TNF-α release and cell proliferation. In these assays, the (R)-bromohydrin diphosphates were, on average, about twice as active as the (S)-bromohydrin diphosphates. In contrast, the (S)-form of EIPP was about twice as active as (R)-EIPP. The activities of the epoxy but-3-enyl diphosphates were both very low. These results suggest that chiral phosphoantigens, as opposed to racemic mixtures, may have utility in immunotherapy." @default.
- W2017496941 created "2016-06-24" @default.
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- W2017496941 date "1965-01-01" @default.
- W2017496941 modified "2023-09-25" @default.
- W2017496941 title "The separation of diazonium salt by thin-layer chromatogrphy" @default.
- W2017496941 cites W1484264113 @default.
- W2017496941 doi "https://doi.org/10.1016/s0021-9673(01)97439-4" @default.
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