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- W2017498309 abstract "Glucose turnover, plasma lactate, FFA, and insulin levels were measured on trained, unanesthetized dogs with indwelling arterial and venous catheters. 2-t-Glucose was used as a tracer according to the primed-constant rate infusion technique to estimate the rate of appearance (Ra) of glucose in and its disappearance (Rd) from the plasma. After establishing base-line values, glucagon (30 or 60 ng/kg/min) or glucose (4.5, 7.5, or 15 mg/kg/min) was infused for 135 min. In normal dogs, glucagon increased the plasma , Ra + 1.2 mg/kg/min and caused a transient decrease of plasma FFA. Three days of treatment with methylprednisolone (3–3.5 mg/kg/day) almost doubled the glucose turnover at only slightly elevated plasma glucose and insulin levels. This treatment strikingly potentiated the effect of glucagon on the hepatic glucose output (20-fold) and on plasma sugar (12-fold). In these animals, glucagon also caused a greater decrease of FFA and a greater rise of insulin levels. Plasma lactate was not altered significantly by glucagon. Infusion of glucose decreased Ra and increased Rd to nearly the same extent in both groups. However, the FFA lowering effect of glucose infusion was less pronounced after glucocorticoid treatment. It is concluded that one of the most spectacular consequences of a brief treatment with large doses of glucocorticoid is the greatly increased effect of glucagon on hepatic glycogenolysis. The possible mechanism of this synergism is discussed." @default.
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- W2017498309 title "Effect of glucagon and glucose load on glucose kinetics, plasma FFA, and insulin in dogs treated with methylprednisolone" @default.
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- W2017498309 doi "https://doi.org/10.1016/0026-0495(73)90027-9" @default.
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