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- W2017501004 abstract "Intravenous infusion of mice with viable allogeneic lymphocytes can produce donor-specific enhancement of skin graft survival, but only if the injected lymphocytes can persist in the host's recirculating lymphocyte pool for at least 3 days. We have investigated the relative roles of class I and class II MHC for C57BL/6 mice infused with lymphoid cells from co-isogenic strains mutated at class I MHC (bm1) or class II MHC (bm12), and for A.TH lymphoid cells infused into C3H (class I different, class II identical) or A.TH (class II different, class I identical). Injected cells differing from the host at class I MHC, but not at class II MHC, can be rapidly removed by host natural immune mechanisms (probably NK cells). Persistence is favored if the injected cells also carry host class I MHC, i.e., tolerance is more readily induced by injecting F1 (A x B) into A rather than B into A, consistent with the missing self hypothesis of NK recognition, with class I MHC being the relevant self-marker. Injected cells differing from the host at class II MHC but not at class I MHC always persist for at least 3 days, even when class I-different cells are being actively removed." @default.
- W2017501004 created "2016-06-24" @default.
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- W2017501004 date "1994-04-01" @default.
- W2017501004 modified "2023-10-03" @default.
- W2017501004 title "CORRELATION BETWEEN LYMPHOCYTE-INDUCED DONOR-SPECIFIC TOLERANCE AND DONOR CELL RECIRCULATION" @default.
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- W2017501004 doi "https://doi.org/10.1097/00007890-199404000-00017" @default.
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