FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017502093> ?p ?o ?g. }

• W2017502093 endingPage "354" @default.
• W2017502093 startingPage "350" @default.
• W2017502093 abstract "The immunological mechanisms of diabetes onset in NOD mice are poorly characterized. Unanue and co-workers find that insulin peptide–reactive (but not insulin protein–reactive) type B T cells can cause diabetes. In addition to the genetic framework, there are two other critical requirements for the development of tissue-specific autoimmune disease. First, autoreactive T cells need to escape thymic negative selection. Second, they need to find suitable conditions for autoantigen presentation and activation in the target tissue. We show here that these two conditions are fulfilled in diabetic mice of the nonobese diabetic (NOD) strain. A set of autoreactive CD4+ T cells specific for an insulin peptide, with the noteworthy feature of not recognizing the insulin protein when processed by antigen-presenting cells (APCs), escaped thymic control, participated in diabetes and caused disease. Moreover, APCs in close contact with beta cells in the islets of Langerhans bore vesicles with the antigenic insulin peptides and activated peptide-specific T cells. Our findings may be relevant for other cases of endocrine autoimmunity." @default.
• W2017502093 created "2016-06-24" @default.
• W2017502093 creator A5015093821 @default.
• W2017502093 creator A5016491150 @default.
• W2017502093 creator A5038680778 @default.
• W2017502093 creator A5049551161 @default.
• W2017502093 creator A5071890597 @default.
• W2017502093 creator A5079811330 @default.
• W2017502093 date "2010-02-28" @default.
• W2017502093 modified "2023-10-17" @default.
• W2017502093 title "Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes" @default.
• W2017502093 cites W1502510454 @default.
• W2017502093 cites W1507845819 @default.
• W2017502093 cites W1577058011 @default.
• W2017502093 cites W1608368846 @default.
• W2017502093 cites W1970876023 @default.
• W2017502093 cites W1971857925 @default.
• W2017502093 cites W1976851725 @default.
• W2017502093 cites W1977972719 @default.
• W2017502093 cites W1984676370 @default.
• W2017502093 cites W1986975744 @default.
• W2017502093 cites W2001882980 @default.
• W2017502093 cites W2020206943 @default.
• W2017502093 cites W2026468137 @default.
• W2017502093 cites W2029853959 @default.
• W2017502093 cites W2031426031 @default.
• W2017502093 cites W2039481522 @default.
• W2017502093 cites W2049740824 @default.
• W2017502093 cites W2056228909 @default.
• W2017502093 cites W2064056403 @default.
• W2017502093 cites W2064671266 @default.
• W2017502093 cites W2065042783 @default.
• W2017502093 cites W2069835331 @default.
• W2017502093 cites W2075640537 @default.
• W2017502093 cites W2082137006 @default.
• W2017502093 cites W2084187309 @default.
• W2017502093 cites W2099495094 @default.
• W2017502093 cites W2105914942 @default.
• W2017502093 cites W2107144645 @default.
• W2017502093 cites W2109459347 @default.
• W2017502093 cites W2112007460 @default.
• W2017502093 cites W2121789150 @default.
• W2017502093 cites W2126278946 @default.
• W2017502093 cites W2144164666 @default.
• W2017502093 cites W2144177716 @default.
• W2017502093 cites W2149271731 @default.
• W2017502093 cites W2171435018 @default.
• W2017502093 doi "https://doi.org/10.1038/ni.1850" @default.
• W2017502093 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3080751" @default.
• W2017502093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20190756" @default.
• W2017502093 hasPublicationYear "2010" @default.
• W2017502093 type Work @default.
• W2017502093 sameAs 2017502093 @default.
• W2017502093 citedByCount "155" @default.
• W2017502093 countsByYear W20175020932012 @default.
• W2017502093 countsByYear W20175020932013 @default.
• W2017502093 countsByYear W20175020932014 @default.
• W2017502093 countsByYear W20175020932015 @default.
• W2017502093 countsByYear W20175020932016 @default.
• W2017502093 countsByYear W20175020932017 @default.
• W2017502093 countsByYear W20175020932018 @default.
• W2017502093 countsByYear W20175020932019 @default.
• W2017502093 countsByYear W20175020932020 @default.
• W2017502093 countsByYear W20175020932021 @default.
• W2017502093 countsByYear W20175020932022 @default.
• W2017502093 countsByYear W20175020932023 @default.
• W2017502093 crossrefType "journal-article" @default.
• W2017502093 hasAuthorship W2017502093A5015093821 @default.
• W2017502093 hasAuthorship W2017502093A5016491150 @default.
• W2017502093 hasAuthorship W2017502093A5038680778 @default.
• W2017502093 hasAuthorship W2017502093A5049551161 @default.
• W2017502093 hasAuthorship W2017502093A5071890597 @default.
• W2017502093 hasAuthorship W2017502093A5079811330 @default.
• W2017502093 hasBestOaLocation W20175020932 @default.
• W2017502093 hasConcept C126322002 @default.
• W2017502093 hasConcept C134018914 @default.
• W2017502093 hasConcept C147483822 @default.
• W2017502093 hasConcept C159654299 @default.
• W2017502093 hasConcept C165220095 @default.
• W2017502093 hasConcept C203014093 @default.
• W2017502093 hasConcept C2776090121 @default.
• W2017502093 hasConcept C2778013207 @default.
• W2017502093 hasConcept C2779075594 @default.
• W2017502093 hasConcept C2779306644 @default.
• W2017502093 hasConcept C2780130043 @default.
• W2017502093 hasConcept C2781232474 @default.
• W2017502093 hasConcept C555293320 @default.
• W2017502093 hasConcept C55851684 @default.
• W2017502093 hasConcept C67662055 @default.
• W2017502093 hasConcept C71924100 @default.
• W2017502093 hasConcept C86803240 @default.
• W2017502093 hasConcept C8891405 @default.
• W2017502093 hasConceptScore W2017502093C126322002 @default.
• W2017502093 hasConceptScore W2017502093C134018914 @default.
• W2017502093 hasConceptScore W2017502093C147483822 @default.
• W2017502093 hasConceptScore W2017502093C159654299 @default.
• W2017502093 hasConceptScore W2017502093C165220095 @default.
• W2017502093 hasConceptScore W2017502093C203014093 @default.

• next