Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017506602> ?p ?o ?g. }
- W2017506602 endingPage "129" @default.
- W2017506602 startingPage "121" @default.
- W2017506602 abstract "AIDS therapies employing HIV protease inhibitors (PIs) are associated with changes in fat metabolism. However, the cellular mechanisms affected by PIs are not clear. Thus, the affects of PIs on adipocyte differentiation were examined in vitro using C3H10T1/2 stem cells. In these cells the PIs, nelfinavir, saquinavir, and ritonavir, reduced triglyceride accumulation, lipogenesis, and expression of the adipose markers, aP2 and LPL. Histological analysis revealed nelfinavir, saquinavir and ritonavir treatment decreased oil red O-staining of cytoplasmic fat droplets. Inhibition occurred in the presence of the RXR agonist LGD1069, indicating the inhibitory effects were not due to an absence of RXR ligand. Moreover, these three PIs increased acute lipolysis in adipocytes. In contrast, two HIV PIs, amprenavir and indinavir, had little effect on lipolysis, lipogenesis, or expression of aP2 and LPL. Although, saquinavir, inhibited ligand-binding to PPARγ with an IC50 of 12.7±3.2 μM, none of the other PIs bound to the nuclear receptors RXRα or PPARγ, (IC50s>20 μM), suggesting that inhibition of adipogenesis is not due to antagonism of ligand binding to RXRα or PPARγ. Taken together, the results suggest that some, but not all, PIs block adipogenesis and stimulate fat catabolism in vitro and this may contribute to the effects of PIs on metabolism in the clinic." @default.
- W2017506602 created "2016-06-24" @default.
- W2017506602 creator A5010595623 @default.
- W2017506602 creator A5011963950 @default.
- W2017506602 creator A5029632697 @default.
- W2017506602 creator A5033022984 @default.
- W2017506602 creator A5042989901 @default.
- W2017506602 creator A5044622632 @default.
- W2017506602 creator A5047492551 @default.
- W2017506602 creator A5055363793 @default.
- W2017506602 date "2000-08-01" @default.
- W2017506602 modified "2023-10-14" @default.
- W2017506602 title "HIV protease inhibitors block adipogenesis and increase lipolysis in vitro" @default.
- W2017506602 cites W149212049 @default.
- W2017506602 cites W1672804368 @default.
- W2017506602 cites W1825676530 @default.
- W2017506602 cites W1968828365 @default.
- W2017506602 cites W1978724449 @default.
- W2017506602 cites W1978902758 @default.
- W2017506602 cites W1981683878 @default.
- W2017506602 cites W1982872424 @default.
- W2017506602 cites W1986618571 @default.
- W2017506602 cites W1989050470 @default.
- W2017506602 cites W1994109490 @default.
- W2017506602 cites W1996499493 @default.
- W2017506602 cites W2000821877 @default.
- W2017506602 cites W2003403009 @default.
- W2017506602 cites W2008722779 @default.
- W2017506602 cites W2026306987 @default.
- W2017506602 cites W2040626489 @default.
- W2017506602 cites W2041841997 @default.
- W2017506602 cites W2047591801 @default.
- W2017506602 cites W2056630493 @default.
- W2017506602 cites W2057924404 @default.
- W2017506602 cites W2060210361 @default.
- W2017506602 cites W2061542670 @default.
- W2017506602 cites W2065000704 @default.
- W2017506602 cites W2069301068 @default.
- W2017506602 cites W2074216064 @default.
- W2017506602 cites W2077039378 @default.
- W2017506602 cites W2084332399 @default.
- W2017506602 cites W2121029272 @default.
- W2017506602 cites W2121690400 @default.
- W2017506602 cites W2122204312 @default.
- W2017506602 cites W2130197700 @default.
- W2017506602 cites W2142144836 @default.
- W2017506602 cites W2155846381 @default.
- W2017506602 cites W2161908322 @default.
- W2017506602 cites W2164015929 @default.
- W2017506602 cites W2171030070 @default.
- W2017506602 cites W2318289184 @default.
- W2017506602 cites W2324473093 @default.
- W2017506602 cites W2327500598 @default.
- W2017506602 cites W3026032990 @default.
- W2017506602 cites W4233396486 @default.
- W2017506602 doi "https://doi.org/10.1016/s0166-3542(00)00102-9" @default.
- W2017506602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10996400" @default.
- W2017506602 hasPublicationYear "2000" @default.
- W2017506602 type Work @default.
- W2017506602 sameAs 2017506602 @default.
- W2017506602 citedByCount "156" @default.
- W2017506602 countsByYear W20175066022012 @default.
- W2017506602 countsByYear W20175066022013 @default.
- W2017506602 countsByYear W20175066022014 @default.
- W2017506602 countsByYear W20175066022015 @default.
- W2017506602 countsByYear W20175066022016 @default.
- W2017506602 countsByYear W20175066022017 @default.
- W2017506602 countsByYear W20175066022018 @default.
- W2017506602 countsByYear W20175066022022 @default.
- W2017506602 crossrefType "journal-article" @default.
- W2017506602 hasAuthorship W2017506602A5010595623 @default.
- W2017506602 hasAuthorship W2017506602A5011963950 @default.
- W2017506602 hasAuthorship W2017506602A5029632697 @default.
- W2017506602 hasAuthorship W2017506602A5033022984 @default.
- W2017506602 hasAuthorship W2017506602A5042989901 @default.
- W2017506602 hasAuthorship W2017506602A5044622632 @default.
- W2017506602 hasAuthorship W2017506602A5047492551 @default.
- W2017506602 hasAuthorship W2017506602A5055363793 @default.
- W2017506602 hasConcept C122927707 @default.
- W2017506602 hasConcept C126322002 @default.
- W2017506602 hasConcept C134018914 @default.
- W2017506602 hasConcept C140985366 @default.
- W2017506602 hasConcept C141359234 @default.
- W2017506602 hasConcept C142462285 @default.
- W2017506602 hasConcept C171089720 @default.
- W2017506602 hasConcept C185592680 @default.
- W2017506602 hasConcept C203014093 @default.
- W2017506602 hasConcept C2776175234 @default.
- W2017506602 hasConcept C2776937687 @default.
- W2017506602 hasConcept C2777210460 @default.
- W2017506602 hasConcept C2781160516 @default.
- W2017506602 hasConcept C2993143319 @default.
- W2017506602 hasConcept C3013748606 @default.
- W2017506602 hasConcept C71924100 @default.
- W2017506602 hasConcept C86803240 @default.
- W2017506602 hasConcept C98274493 @default.
- W2017506602 hasConceptScore W2017506602C122927707 @default.
- W2017506602 hasConceptScore W2017506602C126322002 @default.