FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017506664> ?p ?o ?g. }

• W2017506664 endingPage "153" @default.
• W2017506664 startingPage "145" @default.
• W2017506664 abstract "Recurrent pleural effusions are common complications of hospitalized patients with human immunodeficiency virus (HIV) infection and may pose difficult diagnostic dilemmas. A common cause of recurrent pleural effusions in up to 30% of HIV-seropositive patients is pulmonary involvement by Kaposi's sarcoma, a human herpesvirus 8 (HHV 8)-related neoplasm. The pathogenesis of these effusions is unclear. These recurrent effusions, although benign, have shown significant mesothelial atypia/reactive changes of uncertain etiology. We attempted to evaluate these effusions morphologically and molecularly for the presence of HHV 8, with particular attention to mesothelial cells. All recurrent pleural effusions, as defined by any effusion tapped for cytological examination on more than two occasions, in HIV-positive patients at the National Institutes of Health were examined from 1998 to the present. Cases were stratified according to patients with and without histologically confirmed HHV 8 disease manifestations. Five patients with HHV 8 diseases (four with disseminated Kaposi's sarcoma and one with Castleman's disease) were identified. As a control group, five effusions from HIV-seropositive patients without known HHV 8-related diseases were identified. Cytological examination of effusions in patients with HHV 8-related diseases demonstrated atypical/markedly reactive mesothelial cells accompanied by a polymorphous background of lymphocytes. Molecular studies for B- and T-cell clonality in microdissected whole samples showed no definitive clones in these cases. Conversely, polymerase chain reaction (PCR) studies for the HHV 8 virus was positive in these samples. PCR studies on pure populations of microdissected mesothelial cells from the HHV 8-related effusions were positive for HHV 8 sequences, whereas those from HIV patients with non-HHV 8 related diseases were negative. Immunohistochemistry for HHV 8 (monoclonal antibody to latent nuclear antigen (LNA-1; ORF-73) on cellblock material demonstrated scattered positive mesothelial cells in three of the five cases of HHV 8-associated effusions. HHV 8 has been recently implicated in the pathogenesis of Kaposi's sarcoma and primary effusion lymphoma. Mesothelial cells in recurrent pleural effusions from patients with Kaposi's sarcoma and Castleman's disease appear to be infected with HHV 8. Additional studies need to be done to define the role of mesothelial cell infection in the pathogenesis of these HHV 8-associated effusions and define the prognostic significance." @default.
• W2017506664 created "2016-06-24" @default.
• W2017506664 creator A5024236466 @default.
• W2017506664 creator A5024701461 @default.
• W2017506664 creator A5041169651 @default.
• W2017506664 creator A5049385918 @default.
• W2017506664 creator A5050726526 @default.
• W2017506664 creator A5055705591 @default.
• W2017506664 creator A5060499224 @default.
• W2017506664 creator A5085564237 @default.
• W2017506664 date "2003-02-01" @default.
• W2017506664 modified "2023-10-11" @default.
• W2017506664 title "Infection of Mesothelial Cells with Human Herpes Virus 8 in Human Immunodeficiency Virus–Infected Patients with Kaposi’s Sarcoma, Castleman’s Disease, and Recurrent Pleural Effusions" @default.
• W2017506664 cites W1635039246 @default.
• W2017506664 cites W1662956512 @default.
• W2017506664 cites W1946172505 @default.
• W2017506664 cites W1966150862 @default.
• W2017506664 cites W1975397139 @default.
• W2017506664 cites W1991315179 @default.
• W2017506664 cites W1995048352 @default.
• W2017506664 cites W2014361173 @default.
• W2017506664 cites W2028840705 @default.
• W2017506664 cites W2032438721 @default.
• W2017506664 cites W2048115071 @default.
• W2017506664 cites W2065537276 @default.
• W2017506664 cites W2065953547 @default.
• W2017506664 cites W2084473128 @default.
• W2017506664 cites W2089470376 @default.
• W2017506664 cites W2091413909 @default.
• W2017506664 cites W2105130408 @default.
• W2017506664 cites W2105951668 @default.
• W2017506664 cites W2109847775 @default.
• W2017506664 cites W2111503140 @default.
• W2017506664 cites W2126726717 @default.
• W2017506664 cites W2132747642 @default.
• W2017506664 cites W2137819483 @default.
• W2017506664 cites W2160148218 @default.
• W2017506664 cites W2166243132 @default.
• W2017506664 cites W2329754048 @default.
• W2017506664 cites W2415190071 @default.
• W2017506664 cites W4254732152 @default.
• W2017506664 doi "https://doi.org/10.1097/01.mp.0000052374.61768.79" @default.
• W2017506664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12591967" @default.
• W2017506664 hasPublicationYear "2003" @default.
• W2017506664 type Work @default.
• W2017506664 sameAs 2017506664 @default.
• W2017506664 citedByCount "27" @default.
• W2017506664 countsByYear W20175066642013 @default.
• W2017506664 countsByYear W20175066642017 @default.
• W2017506664 countsByYear W20175066642019 @default.
• W2017506664 countsByYear W20175066642020 @default.
• W2017506664 countsByYear W20175066642022 @default.
• W2017506664 crossrefType "journal-article" @default.
• W2017506664 hasAuthorship W2017506664A5024236466 @default.
• W2017506664 hasAuthorship W2017506664A5024701461 @default.
• W2017506664 hasAuthorship W2017506664A5041169651 @default.
• W2017506664 hasAuthorship W2017506664A5049385918 @default.
• W2017506664 hasAuthorship W2017506664A5050726526 @default.
• W2017506664 hasAuthorship W2017506664A5055705591 @default.
• W2017506664 hasAuthorship W2017506664A5060499224 @default.
• W2017506664 hasAuthorship W2017506664A5085564237 @default.
• W2017506664 hasBestOaLocation W20175066641 @default.
• W2017506664 hasConcept C126322002 @default.
• W2017506664 hasConcept C142724271 @default.
• W2017506664 hasConcept C203014093 @default.
• W2017506664 hasConcept C2522874641 @default.
• W2017506664 hasConcept C2776178081 @default.
• W2017506664 hasConcept C2776517811 @default.
• W2017506664 hasConcept C2777714996 @default.
• W2017506664 hasConcept C2778256501 @default.
• W2017506664 hasConcept C2779594685 @default.
• W2017506664 hasConcept C2779634585 @default.
• W2017506664 hasConcept C2909640154 @default.
• W2017506664 hasConcept C71924100 @default.
• W2017506664 hasConceptScore W2017506664C126322002 @default.
• W2017506664 hasConceptScore W2017506664C142724271 @default.
• W2017506664 hasConceptScore W2017506664C203014093 @default.
• W2017506664 hasConceptScore W2017506664C2522874641 @default.
• W2017506664 hasConceptScore W2017506664C2776178081 @default.
• W2017506664 hasConceptScore W2017506664C2776517811 @default.
• W2017506664 hasConceptScore W2017506664C2777714996 @default.
• W2017506664 hasConceptScore W2017506664C2778256501 @default.
• W2017506664 hasConceptScore W2017506664C2779594685 @default.
• W2017506664 hasConceptScore W2017506664C2779634585 @default.
• W2017506664 hasConceptScore W2017506664C2909640154 @default.
• W2017506664 hasConceptScore W2017506664C71924100 @default.
• W2017506664 hasIssue "2" @default.
• W2017506664 hasLocation W20175066641 @default.
• W2017506664 hasLocation W20175066642 @default.
• W2017506664 hasOpenAccess W2017506664 @default.
• W2017506664 hasPrimaryLocation W20175066641 @default.
• W2017506664 hasRelatedWork W2023169863 @default.
• W2017506664 hasRelatedWork W2033379496 @default.
• W2017506664 hasRelatedWork W2040667109 @default.
• W2017506664 hasRelatedWork W2082929240 @default.
• W2017506664 hasRelatedWork W2086710900 @default.
• W2017506664 hasRelatedWork W2145171916 @default.
• W2017506664 hasRelatedWork W2318585602 @default.

• next