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- W2017506870 abstract "In order to assess the effect of the DNA polymerase inhibitor aphidicolin on resistance to cytosine arabinoside, blast cells from 15 children with ALL and 9 with AML were exposed to a range of concentrations of ara-C +/- aphidicolin. Cell survival was measured using the MTT assay. Aphidicolin significantly increased sensitivity to ara-C in blast cells from both ALL (p=0.001) and AML (p<0.01). The median fold increase (sensitisation ratio) for ALL was 3.4 (range 1.2-13.6) compared to 12.4-fold (range 6.0-148) for AML blasts (p=0.005). There was a striking relationship between increasing ara-C resistance and increasing effect of aphidicolin in AML (p<0.001) but not ALL (p>0.05). These remarkable results suggest that aphidicolin should be considered for future clinical trials as a modulator of ara-C resistance, particularly in AML." @default.
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- W2017506870 date "2003-11-01" @default.
- W2017506870 modified "2023-09-27" @default.
- W2017506870 title "Aphidicolin decreases ex vivo resistance to cytosine arabinoside in childhood acute leukaemia" @default.
- W2017506870 doi "https://doi.org/10.3892/or.10.6.2027" @default.
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