Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017508489> ?p ?o ?g. }
- W2017508489 abstract "Each year schistosomiasis afflicts up to 600 million people in 74 tropical and sub-tropical countries, predominantly in the developing world. Yet we depend on a single drug, praziquantel, for its treatment and control. There is no vaccine available but one is urgently needed especially since praziquantel-resistant parasites are likely to emerge at some time in the future. The disease is caused by several worm species of the genus Schistosoma. These express several classes of papain-like cysteine peptidases, cathepsins B and L, in various tissues but particularly in their gastrodermis where they employ them as digestive enzymes. We have shown that sub-cutaneous injection of recombinant and functionally active S. mansoni cathepsin B1 (SmCB1), or a cathepsin L from a related parasite Fasciola hepatica (FhCL1), elicits highly significant protection (up to 73%) against an experimental challenge worm infection in murine models of schistosomiasis. The immune modulating properties of this subcutaneous injection can boost protection levels (up to 83%) when combined with other S. mansoni vaccine candidates, glyceraldehyde 3-phosphate dehydrogenase (SG3PDH) and peroxiredoxin (PRX-MAP). This cysteine-treatment can also protect mice from S. haematobium infection. Here, we discuss these data in the context of the parasite’s biology and development, and provide putative mechanism by which the native-like cysteine peptidase induce protective immune responses." @default.
- W2017508489 created "2016-06-24" @default.
- W2017508489 creator A5007399225 @default.
- W2017508489 creator A5040944698 @default.
- W2017508489 creator A5048119828 @default.
- W2017508489 creator A5068367604 @default.
- W2017508489 date "2014-05-08" @default.
- W2017508489 modified "2023-10-17" @default.
- W2017508489 title "Induction of protective immune responses against schistosomiasis using functionally active cysteine peptidases" @default.
- W2017508489 cites W109841753 @default.
- W2017508489 cites W1500472831 @default.
- W2017508489 cites W1512472858 @default.
- W2017508489 cites W1563771469 @default.
- W2017508489 cites W1566110452 @default.
- W2017508489 cites W1685974124 @default.
- W2017508489 cites W1755702111 @default.
- W2017508489 cites W1794912145 @default.
- W2017508489 cites W1910765629 @default.
- W2017508489 cites W1965430190 @default.
- W2017508489 cites W1967499606 @default.
- W2017508489 cites W1973272261 @default.
- W2017508489 cites W1973484636 @default.
- W2017508489 cites W1976001645 @default.
- W2017508489 cites W1980432262 @default.
- W2017508489 cites W1982187630 @default.
- W2017508489 cites W1983687616 @default.
- W2017508489 cites W1988834288 @default.
- W2017508489 cites W1994660543 @default.
- W2017508489 cites W1995756596 @default.
- W2017508489 cites W1998550541 @default.
- W2017508489 cites W2002185329 @default.
- W2017508489 cites W2003383012 @default.
- W2017508489 cites W2008375003 @default.
- W2017508489 cites W2019815618 @default.
- W2017508489 cites W2021822509 @default.
- W2017508489 cites W2022101918 @default.
- W2017508489 cites W2025252120 @default.
- W2017508489 cites W2025484591 @default.
- W2017508489 cites W2029267313 @default.
- W2017508489 cites W2037156624 @default.
- W2017508489 cites W2037328598 @default.
- W2017508489 cites W2040469495 @default.
- W2017508489 cites W2046874304 @default.
- W2017508489 cites W2047142949 @default.
- W2017508489 cites W2050070535 @default.
- W2017508489 cites W2051239639 @default.
- W2017508489 cites W2052745593 @default.
- W2017508489 cites W2053491577 @default.
- W2017508489 cites W2058126260 @default.
- W2017508489 cites W2058808796 @default.
- W2017508489 cites W2060450994 @default.
- W2017508489 cites W2063493526 @default.
- W2017508489 cites W2065705117 @default.
- W2017508489 cites W2068467626 @default.
- W2017508489 cites W2069500720 @default.
- W2017508489 cites W2071429505 @default.
- W2017508489 cites W2072190557 @default.
- W2017508489 cites W2072510856 @default.
- W2017508489 cites W2073747182 @default.
- W2017508489 cites W2075093426 @default.
- W2017508489 cites W2077171438 @default.
- W2017508489 cites W2078682911 @default.
- W2017508489 cites W2078909963 @default.
- W2017508489 cites W2080160266 @default.
- W2017508489 cites W2084153471 @default.
- W2017508489 cites W2087853853 @default.
- W2017508489 cites W2088915877 @default.
- W2017508489 cites W2091556637 @default.
- W2017508489 cites W2092637691 @default.
- W2017508489 cites W2093734748 @default.
- W2017508489 cites W2097125253 @default.
- W2017508489 cites W2097311057 @default.
- W2017508489 cites W2099020205 @default.
- W2017508489 cites W2099918954 @default.
- W2017508489 cites W2100422150 @default.
- W2017508489 cites W2106456576 @default.
- W2017508489 cites W2106769312 @default.
- W2017508489 cites W2107506178 @default.
- W2017508489 cites W2109843249 @default.
- W2017508489 cites W2114468987 @default.
- W2017508489 cites W2117649136 @default.
- W2017508489 cites W2128900056 @default.
- W2017508489 cites W2130020291 @default.
- W2017508489 cites W2132206282 @default.
- W2017508489 cites W2132824342 @default.
- W2017508489 cites W2135996116 @default.
- W2017508489 cites W2136451615 @default.
- W2017508489 cites W2136833193 @default.
- W2017508489 cites W2144643729 @default.
- W2017508489 cites W2147013162 @default.
- W2017508489 cites W2147746949 @default.
- W2017508489 cites W2148138050 @default.
- W2017508489 cites W2150464681 @default.
- W2017508489 cites W2151233748 @default.
- W2017508489 cites W2152512778 @default.
- W2017508489 cites W2153236234 @default.
- W2017508489 cites W2154272808 @default.
- W2017508489 cites W2154719091 @default.
- W2017508489 cites W2155321727 @default.
- W2017508489 cites W2159082476 @default.