FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017514599> ?p ?o ?g. }

• W2017514599 endingPage "e35267" @default.
• W2017514599 startingPage "e35267" @default.
• W2017514599 abstract "Background The isothiocyanate sulforaphane (SFN) possesses interesting anticancer activities. However, recent studies reported that SFN promotes the formation of reactive oxygen species (ROS) as well as DNA breakage. Methodology/Principal Findings We investigated whether SFN is able to damage RNA, whose loss of integrity was demonstrated in different chronic diseases. Considering the ability of SFN to protect from genotoxicity, we also examined whether SFN is able to protect from RNA damage induced by different chemicals (doxorubicin, spermine, S-nitroso-N-acetylpenicillamine, H2O2). We observed that SFN was devoid of either RNA damaging and RNA protective activity in human leukemic cells. It was able to potentiate the RNA damage by doxorubicin and spermine. In the first case, the effect was attributable to its ability of modulating the bioreductive activation of doxorubicin. For spermine, the effects were mainly due to its modulation of ROS levels produced by spermine metabolism. As to the cytotoxic relevance of the RNA damage, we found that the treatment of cells with a mixture of spermine or doxorubicin plus SFN increased their proapoptotic potential. Thus it is conceivable that the presence of RNA damage might concur to the overall toxic response induced by a chemical agent in targeted cells. Conclusions/Significance Since RNA is emerging as a potential target for anticancer drugs, its ability to enhance spermine- and doxorubicin-induced RNA damage and cytotoxicity could represent an additional mechanism for the potentiating effects of SFN associated with anticancer drugs." @default.
• W2017514599 created "2016-06-24" @default.
• W2017514599 creator A5010795108 @default.
• W2017514599 creator A5018536698 @default.
• W2017514599 creator A5059450663 @default.
• W2017514599 creator A5063429179 @default.
• W2017514599 creator A5074119826 @default.
• W2017514599 creator A5080651938 @default.
• W2017514599 creator A5090780126 @default.
• W2017514599 date "2012-04-23" @default.
• W2017514599 modified "2023-09-30" @default.
• W2017514599 title "Sulforaphane Potentiates RNA Damage Induced by Different Xenobiotics" @default.
• W2017514599 cites W1696199194 @default.
• W2017514599 cites W1816432249 @default.
• W2017514599 cites W1896970469 @default.
• W2017514599 cites W1967077010 @default.
• W2017514599 cites W1967331918 @default.
• W2017514599 cites W1969789697 @default.
• W2017514599 cites W1971155331 @default.
• W2017514599 cites W1972761041 @default.
• W2017514599 cites W1977524267 @default.
• W2017514599 cites W1983255679 @default.
• W2017514599 cites W1983525877 @default.
• W2017514599 cites W1984254481 @default.
• W2017514599 cites W1984772318 @default.
• W2017514599 cites W1988896647 @default.
• W2017514599 cites W1990741240 @default.
• W2017514599 cites W1999428211 @default.
• W2017514599 cites W2004351327 @default.
• W2017514599 cites W2025054234 @default.
• W2017514599 cites W2028109353 @default.
• W2017514599 cites W2028976892 @default.
• W2017514599 cites W2031924680 @default.
• W2017514599 cites W2038182793 @default.
• W2017514599 cites W2039986962 @default.
• W2017514599 cites W2042322942 @default.
• W2017514599 cites W2044110113 @default.
• W2017514599 cites W2046057607 @default.
• W2017514599 cites W2049196301 @default.
• W2017514599 cites W2052099137 @default.
• W2017514599 cites W2052899635 @default.
• W2017514599 cites W2054251983 @default.
• W2017514599 cites W2062978707 @default.
• W2017514599 cites W2063637433 @default.
• W2017514599 cites W2070522266 @default.
• W2017514599 cites W2072446721 @default.
• W2017514599 cites W2073683178 @default.
• W2017514599 cites W2073883835 @default.
• W2017514599 cites W2078089123 @default.
• W2017514599 cites W2104257107 @default.
• W2017514599 cites W2116394959 @default.
• W2017514599 cites W2119009797 @default.
• W2017514599 cites W2126481808 @default.
• W2017514599 cites W2133198677 @default.
• W2017514599 cites W2134817040 @default.
• W2017514599 cites W2138498649 @default.
• W2017514599 cites W2140907909 @default.
• W2017514599 cites W2141630834 @default.
• W2017514599 cites W2144468407 @default.
• W2017514599 cites W2145044290 @default.
• W2017514599 cites W2147696493 @default.
• W2017514599 cites W2156650816 @default.
• W2017514599 cites W2158430000 @default.
• W2017514599 cites W2160009495 @default.
• W2017514599 cites W2161201019 @default.
• W2017514599 cites W2162416679 @default.
• W2017514599 cites W2171763841 @default.
• W2017514599 cites W4251161705 @default.
• W2017514599 doi "https://doi.org/10.1371/journal.pone.0035267" @default.
• W2017514599 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3335137" @default.
• W2017514599 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22539965" @default.
• W2017514599 hasPublicationYear "2012" @default.
• W2017514599 type Work @default.
• W2017514599 sameAs 2017514599 @default.
• W2017514599 citedByCount "11" @default.
• W2017514599 countsByYear W20175145992013 @default.
• W2017514599 countsByYear W20175145992014 @default.
• W2017514599 countsByYear W20175145992015 @default.
• W2017514599 countsByYear W20175145992016 @default.
• W2017514599 countsByYear W20175145992017 @default.
• W2017514599 countsByYear W20175145992020 @default.
• W2017514599 countsByYear W20175145992023 @default.
• W2017514599 crossrefType "journal-article" @default.
• W2017514599 hasAuthorship W2017514599A5010795108 @default.
• W2017514599 hasAuthorship W2017514599A5018536698 @default.
• W2017514599 hasAuthorship W2017514599A5059450663 @default.
• W2017514599 hasAuthorship W2017514599A5063429179 @default.
• W2017514599 hasAuthorship W2017514599A5074119826 @default.
• W2017514599 hasAuthorship W2017514599A5080651938 @default.
• W2017514599 hasAuthorship W2017514599A5090780126 @default.
• W2017514599 hasBestOaLocation W20175145991 @default.
• W2017514599 hasConcept C104317684 @default.
• W2017514599 hasConcept C143425029 @default.
• W2017514599 hasConcept C153911025 @default.
• W2017514599 hasConcept C178790620 @default.
• W2017514599 hasConcept C181199279 @default.
• W2017514599 hasConcept C185592680 @default.
• W2017514599 hasConcept C2776109719 @default.

• next