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- W2017520168 abstract "The comparative abilities of several naturally-occurring steroids to compete for [3H]oestradiol-17β-binding sites in rat mammary tumour cytosol have been investigated. Apart from compounds containing a phenolic A-ring, the most effective compounds were 5-androstene-3β, 17β-diol, 5-androstene-3α, 17β-diol and 5α-androstane-3β, 17β-diol. 5-Androstene-3β, 17β-diol appears to compete by binding to the same site as oestradiol-17β. Those compounds most effective at diminishing cytoplasmic [3H]oestradiol-17β binding also depressed nuclear binding of [3H]oestradiol-17β. The presence of a nominal oestrogen receptor with a range of affinity for a number of steroids, including potential androgens, may indicate the presence of a regulatory mechanism superimposed on the basic oestrogen controlled system." @default.
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- W2017520168 date "1977-12-01" @default.
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- W2017520168 title "The specificity of the oestrogen receptor of DMBA-induced mammary tumours of the rat" @default.
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- W2017520168 doi "https://doi.org/10.1016/0014-2964(77)90156-6" @default.
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