FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017520924> ?p ?o ?g. }

• W2017520924 endingPage "25" @default.
• W2017520924 startingPage "17" @default.
• W2017520924 abstract "A high purity factor VIII/von Willebrand Factor (FVIII/vWF)concentrate (IMMUNATE * [STIM plus † ])( n = 6 batches), and a high purityfactor IX (FIX) concentrate (IMMUNINE * [STIMplus]) ( n = 7 batches), wereassessed in vitro for their applicability to continuousinfusion. Parameters pertinent to continuous infusion wereinvestigated and included stability, sterility and, in the caseof FIX, the generation of potentially thrombogenic components.Four stationary or transportable mini infusion pumps, equippedwith polyethylene, polypropylene or polyvinylchloride plasticcomponents were used. The concentrates were reconstitutedwithout extra filling volume and perfused at12.5 mL h −1 and1 mL h −1 ; sampling was carriedout at the start of the experiment and for up to 48 h.The FVIII procoagulant activity (FVIII:C) was assayed byamidolytic, 1‐stage and 2‐stage assays; vWF was examined forristocetin cofactor activity, antigen and multimers. The FIXcoagulation activity (FIX:C) was determined by a 1‐stagecoagulation assay; thrombogenicity potential was assessed invivo (Wessler stasis model in rabbits) and invitro (FIXa and nonactivated thromboplastin time).Reconstituted concentrate incubated under the same conditionsserved as a control. Both concentrates remained sterilethroughout the testing period. The perfused and control samplesremained stable, retaining over 95% of activity for FVIII:C andover 90% for FIX:C for up to 48 h. Intermittent decreaseof FVIII:C or FIX:C was not observed, suggesting no adsorptionof FVIII or FIX onto plastic surfaces during either short orlong‐term exposure. No thrombogenic components were detected inthe high purity FIX concentrate. Thus, under the invitro conditions used, FVIII/vWF and FIX were found to besuitable for administration by continuous infusion." @default.
• W2017520924 created "2016-06-24" @default.
• W2017520924 creator A5007552774 @default.
• W2017520924 creator A5016403288 @default.
• W2017520924 creator A5035673773 @default.
• W2017520924 creator A5047997527 @default.
• W2017520924 creator A5048575193 @default.
• W2017520924 creator A5053813820 @default.
• W2017520924 creator A5063894554 @default.
• W2017520924 creator A5070447635 @default.
• W2017520924 creator A5076151217 @default.
• W2017520924 creator A5081509172 @default.
• W2017520924 date "1999-01-01" @default.
• W2017520924 modified "2023-10-11" @default.
• W2017520924 title "Continuous infusion of FVIII and FIX concentrates:<i>in vitro</i>analysis of clinically relevant parameters" @default.
• W2017520924 cites W1504674459 @default.
• W2017520924 cites W1904020067 @default.
• W2017520924 cites W1974118967 @default.
• W2017520924 cites W1979944276 @default.
• W2017520924 cites W1983129316 @default.
• W2017520924 cites W1986859389 @default.
• W2017520924 cites W1989754377 @default.
• W2017520924 cites W2002531170 @default.
• W2017520924 cites W2008004101 @default.
• W2017520924 cites W2011649613 @default.
• W2017520924 cites W2014586564 @default.
• W2017520924 cites W2053635159 @default.
• W2017520924 cites W2063119299 @default.
• W2017520924 cites W2072230435 @default.
• W2017520924 cites W2075548519 @default.
• W2017520924 cites W2075651565 @default.
• W2017520924 cites W207578375 @default.
• W2017520924 cites W2093291439 @default.
• W2017520924 cites W2124382614 @default.
• W2017520924 cites W2136022380 @default.
• W2017520924 cites W2161680269 @default.
• W2017520924 cites W2404846762 @default.
• W2017520924 cites W2415232981 @default.
• W2017520924 cites W2421629999 @default.
• W2017520924 cites W2426395611 @default.
• W2017520924 cites W2430768242 @default.
• W2017520924 cites W38919216 @default.
• W2017520924 cites W4230915316 @default.
• W2017520924 cites W4319053052 @default.
• W2017520924 cites W84925487 @default.
• W2017520924 doi "https://doi.org/10.1046/j.1365-2516.1999.00210.x" @default.
• W2017520924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10215943" @default.
• W2017520924 hasPublicationYear "1999" @default.
• W2017520924 type Work @default.
• W2017520924 sameAs 2017520924 @default.
• W2017520924 citedByCount "12" @default.
• W2017520924 countsByYear W20175209242022 @default.
• W2017520924 crossrefType "journal-article" @default.
• W2017520924 hasAuthorship W2017520924A5007552774 @default.
• W2017520924 hasAuthorship W2017520924A5016403288 @default.
• W2017520924 hasAuthorship W2017520924A5035673773 @default.
• W2017520924 hasAuthorship W2017520924A5047997527 @default.
• W2017520924 hasAuthorship W2017520924A5048575193 @default.
• W2017520924 hasAuthorship W2017520924A5053813820 @default.
• W2017520924 hasAuthorship W2017520924A5063894554 @default.
• W2017520924 hasAuthorship W2017520924A5070447635 @default.
• W2017520924 hasAuthorship W2017520924A5076151217 @default.
• W2017520924 hasAuthorship W2017520924A5081509172 @default.
• W2017520924 hasConcept C126322002 @default.
• W2017520924 hasConcept C150903083 @default.
• W2017520924 hasConcept C185592680 @default.
• W2017520924 hasConcept C202751555 @default.
• W2017520924 hasConcept C203014093 @default.
• W2017520924 hasConcept C207001950 @default.
• W2017520924 hasConcept C2776649359 @default.
• W2017520924 hasConcept C2779394231 @default.
• W2017520924 hasConcept C2781221834 @default.
• W2017520924 hasConcept C55493867 @default.
• W2017520924 hasConcept C71924100 @default.
• W2017520924 hasConcept C86803240 @default.
• W2017520924 hasConcept C89560881 @default.
• W2017520924 hasConceptScore W2017520924C126322002 @default.
• W2017520924 hasConceptScore W2017520924C150903083 @default.
• W2017520924 hasConceptScore W2017520924C185592680 @default.
• W2017520924 hasConceptScore W2017520924C202751555 @default.
• W2017520924 hasConceptScore W2017520924C203014093 @default.
• W2017520924 hasConceptScore W2017520924C207001950 @default.
• W2017520924 hasConceptScore W2017520924C2776649359 @default.
• W2017520924 hasConceptScore W2017520924C2779394231 @default.
• W2017520924 hasConceptScore W2017520924C2781221834 @default.
• W2017520924 hasConceptScore W2017520924C55493867 @default.
• W2017520924 hasConceptScore W2017520924C71924100 @default.
• W2017520924 hasConceptScore W2017520924C86803240 @default.
• W2017520924 hasConceptScore W2017520924C89560881 @default.
• W2017520924 hasIssue "1" @default.
• W2017520924 hasLocation W20175209241 @default.
• W2017520924 hasLocation W20175209242 @default.
• W2017520924 hasOpenAccess W2017520924 @default.
• W2017520924 hasPrimaryLocation W20175209241 @default.
• W2017520924 hasRelatedWork W2001214272 @default.
• W2017520924 hasRelatedWork W2017660893 @default.
• W2017520924 hasRelatedWork W2054136803 @default.
• W2017520924 hasRelatedWork W2138350991 @default.

• next