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• W2017522017 abstract "Cell motility is a crucial component involved in wound healing, development, and tumor metastasis. This study investigated whether extracellular annexins, members of a calcium- and phospholipid-binding family of proteins, play a role in the migration of Lewis lung carcinoma cells. Using assays for wound closure and migration through 8-μm pores, it was found that annexins II and V significantly (>40%) inhibited migration of these highly metastatic cells. Additionally, anti-annexin II antibodies enhanced migration of these same cells in the wound closure assay, while an irrelevant antibody (anti-calmodulin) showed no effect. These effects may be due to annexin–membrane binding and inhibition of phospholipid movement that is necessary for the formation of membrane protrusions." @default.
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• W2017522017 date "1997-12-01" @default.
• W2017522017 modified "2023-10-17" @default.
• W2017522017 title "Annexins II and V Inhibit Cell Migration" @default.
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• W2017522017 doi "https://doi.org/10.1006/excr.1997.3817" @default.
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