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- W2017524203 abstract "The effect of age on the pharmacokinetics of two benzodiazepines, diazepam andlorazepam, was studied.Seven young healthy male volunteers, 22 to 25 years old, and 10 elderly people, aged67 to 90, participated in this study after giving informed written consent. One mg oflorazepam was administered orally to the elderly volunteers, and 2 mg was given to theyoung volunteers. Using two weeks drug-free interval, 5 mg of diazepam was administeredorally to the two groups using randomized experimental protocol based on a Latin squaredesign.Blood samples were drawn for 72 hr and plasma concentrations of diazepam, N-desmethyldiazepam, and lorazepam were determined by electron-capture gas-liquid chromatography. Pharmacokinetic parameters were calculated and comparisons were madebetween the young and the elderly.With diazepam, elimination half. lives (t1/2) of the elderly group (Mean±SD: 86 .3±65.4 hr) were prolonged compared with those of the young (38.6±8.2 hr) at the 5%significance level.The volumes of distribution (Vd) of diazepam in the elderly (1.42±0.83l/kg) weresignificantly larger than those of the young (0.79±0.20) (P<0.05). The t1/2 and Vd oflorazepam in the elderly (29.6±16.7 hr, 1.35±0.46l/kg respectively), were not significantlydifferent from those of the young (18.4±3.7 hr, 1.48±0.58l/kg respectively); however, clearance of lorazepam in the young (57.03±21.09ml/hr/kg) was higher than in theelderly (35.42±10.63ml/hr/kg) (P<0.05). Clearances of diazepam in the young and inthe elderly were nearly identical." @default.
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- W2017524203 date "1988-01-01" @default.
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- W2017524203 title "Age difference in kinetics of diazepam and lorazepam in man." @default.
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- W2017524203 doi "https://doi.org/10.3999/jscpt.19.591" @default.
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