FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017526058> ?p ?o ?g. }

• W2017526058 endingPage "1365" @default.
• W2017526058 startingPage "1361" @default.
• W2017526058 abstract "In patients with acute respiratory distress syndrome (ARDS), permissive hypercapnia is a strategy to decrease airway pressures to prevent ventilator-induced lung damage by lowering tidal volumes and tolerating higher arterial carbon dioxide tension. However, in experimental studies hypercapnia impairs myocardial contractility and hemodynamic function. We investigated the effect of short-term permissive hypercapnia on myocardial contractility and hemodynamics in patients with ARDS. We hypothesized that the administration of tromethamine (THAM), a buffer which does not increase carbon dioxide production, would modify these changes. In 12 patients with ARDS, permissive hypercapnia was implemented for 2 h with a target Pa(CO(2))of 80 mm Hg. Patients were randomized to have respiratory acidosis corrected by THAM (pH-corrected group), or not corrected (pH-uncorrected group). Hemodynamic responses were measured, and transesophageal echocardiography (TEE) was used to determine myocardial contractility. Permissive hypercapnia resulted in significant decreases in systemic vascular resistance (SVR) and increases in cardiac output (Q). Myocardial contractility decreased in both groups but significantly less in the pH-corrected group (approximately 10%) than in the pH-uncorrected group (approximately 18%, p < 0.05). Mean arterial pressure decreased and mean pulmonary arterial pressure increased significantly only in the pH-uncorrected group. All values returned to baseline conditions 1 h after permissive hypercapnia was terminated. Our study demonstrates a reversible depression of myocardial contractility and hemodynamic alterations during rapid permissive hypercapnia which were attenuated by buffering with THAM. This may have applicability to the clinical strategy of permissive hypercapnia and allow the benefit of decreased airway pressures to be realized while minimizing the adverse hemodynamic effects of hypercapnic acidosis." @default.
• W2017526058 created "2016-06-24" @default.
• W2017526058 creator A5025815034 @default.
• W2017526058 creator A5026671569 @default.
• W2017526058 creator A5052811744 @default.
• W2017526058 creator A5061286711 @default.
• W2017526058 creator A5063351458 @default.
• W2017526058 creator A5072736231 @default.
• W2017526058 creator A5084267136 @default.
• W2017526058 creator A5088689903 @default.
• W2017526058 date "2000-10-01" @default.
• W2017526058 modified "2023-10-18" @default.
• W2017526058 title "Tromethamine Buffer Modifies the Depressant Effect of Permissive Hypercapnia on Myocardial Contractility in Patients with Acute Respiratory Distress Syndrome" @default.
• W2017526058 cites W1985195797 @default.
• W2017526058 cites W1997920871 @default.
• W2017526058 cites W2001789405 @default.
• W2017526058 cites W2008235928 @default.
• W2017526058 cites W2010432684 @default.
• W2017526058 cites W2018906705 @default.
• W2017526058 cites W2019980095 @default.
• W2017526058 cites W2047985166 @default.
• W2017526058 cites W2067161021 @default.
• W2017526058 cites W2092862657 @default.
• W2017526058 cites W2095573474 @default.
• W2017526058 cites W2105954454 @default.
• W2017526058 cites W2106311731 @default.
• W2017526058 cites W2111744294 @default.
• W2017526058 cites W2117631539 @default.
• W2017526058 cites W2121285193 @default.
• W2017526058 cites W2129966847 @default.
• W2017526058 cites W2134224532 @default.
• W2017526058 cites W2143748013 @default.
• W2017526058 cites W2145950740 @default.
• W2017526058 cites W2161328469 @default.
• W2017526058 cites W2167191297 @default.
• W2017526058 cites W2333922183 @default.
• W2017526058 cites W65714835 @default.
• W2017526058 doi "https://doi.org/10.1164/ajrccm.162.4.9808092" @default.
• W2017526058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11029345" @default.
• W2017526058 hasPublicationYear "2000" @default.
• W2017526058 type Work @default.
• W2017526058 sameAs 2017526058 @default.
• W2017526058 citedByCount "115" @default.
• W2017526058 countsByYear W20175260582012 @default.
• W2017526058 countsByYear W20175260582013 @default.
• W2017526058 countsByYear W20175260582014 @default.
• W2017526058 countsByYear W20175260582015 @default.
• W2017526058 countsByYear W20175260582016 @default.
• W2017526058 countsByYear W20175260582017 @default.
• W2017526058 countsByYear W20175260582018 @default.
• W2017526058 countsByYear W20175260582019 @default.
• W2017526058 countsByYear W20175260582020 @default.
• W2017526058 countsByYear W20175260582021 @default.
• W2017526058 countsByYear W20175260582022 @default.
• W2017526058 countsByYear W20175260582023 @default.
• W2017526058 crossrefType "journal-article" @default.
• W2017526058 hasAuthorship W2017526058A5025815034 @default.
• W2017526058 hasAuthorship W2017526058A5026671569 @default.
• W2017526058 hasAuthorship W2017526058A5052811744 @default.
• W2017526058 hasAuthorship W2017526058A5061286711 @default.
• W2017526058 hasAuthorship W2017526058A5063351458 @default.
• W2017526058 hasAuthorship W2017526058A5072736231 @default.
• W2017526058 hasAuthorship W2017526058A5084267136 @default.
• W2017526058 hasAuthorship W2017526058A5088689903 @default.
• W2017526058 hasConcept C126322002 @default.
• W2017526058 hasConcept C139940330 @default.
• W2017526058 hasConcept C164705383 @default.
• W2017526058 hasConcept C178853913 @default.
• W2017526058 hasConcept C2776348555 @default.
• W2017526058 hasConcept C2777037550 @default.
• W2017526058 hasConcept C2777714996 @default.
• W2017526058 hasConcept C2778553927 @default.
• W2017526058 hasConcept C39133596 @default.
• W2017526058 hasConcept C42219234 @default.
• W2017526058 hasConcept C71924100 @default.
• W2017526058 hasConceptScore W2017526058C126322002 @default.
• W2017526058 hasConceptScore W2017526058C139940330 @default.
• W2017526058 hasConceptScore W2017526058C164705383 @default.
• W2017526058 hasConceptScore W2017526058C178853913 @default.
• W2017526058 hasConceptScore W2017526058C2776348555 @default.
• W2017526058 hasConceptScore W2017526058C2777037550 @default.
• W2017526058 hasConceptScore W2017526058C2777714996 @default.
• W2017526058 hasConceptScore W2017526058C2778553927 @default.
• W2017526058 hasConceptScore W2017526058C39133596 @default.
• W2017526058 hasConceptScore W2017526058C42219234 @default.
• W2017526058 hasConceptScore W2017526058C71924100 @default.
• W2017526058 hasIssue "4" @default.
• W2017526058 hasLocation W20175260581 @default.
• W2017526058 hasLocation W20175260582 @default.
• W2017526058 hasOpenAccess W2017526058 @default.
• W2017526058 hasPrimaryLocation W20175260581 @default.
• W2017526058 hasRelatedWork W195539535 @default.
• W2017526058 hasRelatedWork W1993774333 @default.
• W2017526058 hasRelatedWork W2016846781 @default.
• W2017526058 hasRelatedWork W2017526058 @default.
• W2017526058 hasRelatedWork W2025804483 @default.
• W2017526058 hasRelatedWork W2285672337 @default.
• W2017526058 hasRelatedWork W2408235406 @default.

• next