Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017532571> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2017532571 abstract "Purpose:Dose inhomogeneity is inherent to high dose rate (HDR) brachytherapy treatment technique. The use of the generalized equivalent uniform dose (gEUD) in the objective function used for the optimization process is suggested as more effective in addressing inhomogeneity, compared to dose‐ or dose‐volume‐ based objectives. The purpose of the current work is to introduce and study a gEUD‐based objective function in HDR brachytherapytreatment planningoptimization.Method and Materials: A gEUD‐based objective function was used to optimize HDR prostate brachytherapy treatment plans for 12 patients. The quality of these plans has been compared to alternative, dose‐based optimized plans, generated by HIPO, a commercially available optimizer, as implemented in Oncentra Prostate v3.1. The comparison was based on dose‐volume‐histograms (DVHs) and biological indices for each plan. Results: DVH comparisons between the two optimization methods indicate that the gEUD‐based optimization model can lead to equivalent or better target coverage while better sparing the normal tissue structures than the dose‐based optimized plans. Comparisons of the resulting gEUD values for each structure and plan showed a statistically significant improvement in normal tissue sparing (6.9% decrease in gEUD values for the bladder and 2.2% for the rectum on average) for the same or better target coverage (1.1% average increase in the gEUD values). Conclusion: The results of this study indicate that biologically‐based optimization can significantly improve the quality of the treatment plan in HDR brachytherapy. Considering the very high doses per fraction delivered by this treatment method, better sparing of the normal tissue structures obtained by gEUD‐based optimization may be of high importance for the patient's clinical outcome." @default.
- W2017532571 created "2016-06-24" @default.
- W2017532571 creator A5011977189 @default.
- W2017532571 creator A5021753469 @default.
- W2017532571 creator A5067179752 @default.
- W2017532571 creator A5070556980 @default.
- W2017532571 creator A5082694720 @default.
- W2017532571 creator A5089050618 @default.
- W2017532571 date "2010-06-01" @default.
- W2017532571 modified "2023-10-02" @default.
- W2017532571 title "MO-E-BRB-03: High Dose Rate Brachytherapy Optimization Based on the Generalized Equivalent Uniform Dose" @default.
- W2017532571 doi "https://doi.org/10.1118/1.3469113" @default.
- W2017532571 hasPublicationYear "2010" @default.
- W2017532571 type Work @default.
- W2017532571 sameAs 2017532571 @default.
- W2017532571 citedByCount "0" @default.
- W2017532571 crossrefType "journal-article" @default.
- W2017532571 hasAuthorship W2017532571A5011977189 @default.
- W2017532571 hasAuthorship W2017532571A5021753469 @default.
- W2017532571 hasAuthorship W2017532571A5067179752 @default.
- W2017532571 hasAuthorship W2017532571A5070556980 @default.
- W2017532571 hasAuthorship W2017532571A5082694720 @default.
- W2017532571 hasAuthorship W2017532571A5089050618 @default.
- W2017532571 hasConcept C126838900 @default.
- W2017532571 hasConcept C201645570 @default.
- W2017532571 hasConcept C2777416452 @default.
- W2017532571 hasConcept C2780198649 @default.
- W2017532571 hasConcept C2989005 @default.
- W2017532571 hasConcept C33923547 @default.
- W2017532571 hasConcept C509974204 @default.
- W2017532571 hasConcept C71924100 @default.
- W2017532571 hasConcept C75088862 @default.
- W2017532571 hasConceptScore W2017532571C126838900 @default.
- W2017532571 hasConceptScore W2017532571C201645570 @default.
- W2017532571 hasConceptScore W2017532571C2777416452 @default.
- W2017532571 hasConceptScore W2017532571C2780198649 @default.
- W2017532571 hasConceptScore W2017532571C2989005 @default.
- W2017532571 hasConceptScore W2017532571C33923547 @default.
- W2017532571 hasConceptScore W2017532571C509974204 @default.
- W2017532571 hasConceptScore W2017532571C71924100 @default.
- W2017532571 hasConceptScore W2017532571C75088862 @default.
- W2017532571 hasLocation W20175325711 @default.
- W2017532571 hasOpenAccess W2017532571 @default.
- W2017532571 hasPrimaryLocation W20175325711 @default.
- W2017532571 hasRelatedWork W1979502109 @default.
- W2017532571 hasRelatedWork W1985167221 @default.
- W2017532571 hasRelatedWork W1991060018 @default.
- W2017532571 hasRelatedWork W1995857804 @default.
- W2017532571 hasRelatedWork W1997319919 @default.
- W2017532571 hasRelatedWork W1999999701 @default.
- W2017532571 hasRelatedWork W2010168008 @default.
- W2017532571 hasRelatedWork W2018223807 @default.
- W2017532571 hasRelatedWork W2047496483 @default.
- W2017532571 hasRelatedWork W2052353139 @default.
- W2017532571 hasRelatedWork W2053630701 @default.
- W2017532571 hasRelatedWork W2166010438 @default.
- W2017532571 hasRelatedWork W2185593531 @default.
- W2017532571 hasRelatedWork W2512923753 @default.
- W2017532571 hasRelatedWork W2514091492 @default.
- W2017532571 hasRelatedWork W2599249710 @default.
- W2017532571 hasRelatedWork W2745819507 @default.
- W2017532571 hasRelatedWork W2895533685 @default.
- W2017532571 hasRelatedWork W3093052621 @default.
- W2017532571 hasRelatedWork W2113764173 @default.
- W2017532571 isParatext "false" @default.
- W2017532571 isRetracted "false" @default.
- W2017532571 magId "2017532571" @default.
- W2017532571 workType "article" @default.